TY - JOUR
T1 - PIGMENTED VILLONODULAR SYNOVITIS in A RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS)
AU - Ihms, Elizabeth A.
AU - Rivas, Anne
AU - Bronson, Ellen
AU - Mangus, Lisa M.
N1 - Publisher Copyright:
© Copyright 2017 by American Association of Zoo Veterinarians.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - A 17-yr-old, female, captive-born reticulated giraffe (Giraffa camelopardalis) presented with acute-onset lameness of the right metacarpophalangeal (fetlock) joint. Despite multiple courses of treatment, the lameness and swelling progressively worsened over a 3.5-yr period, and the giraffe was euthanized. At necropsy, gross and microscopic changes in the right, front fetlock and associated flexor tendon sheath included villous synovial hyperplasia and the formation of discrete pigmented nodules within synovial membranes. Histologically, the nodules were composed of abundant, fibrous connective tissue with heavy macrophage infiltration, hemosiderin deposition, and distinctive, multinucleated cells that resembled osteoclasts. These findings were consistent with pigmented villonodular synovitis (PVNS), a rare condition affecting both humans and animals. Although the pathophysiology of PVNS is poorly understood, lesions exhibit features of both neoplastic and reactive inflammatory processes. This case report represents, to the authors' knowledge, the first description of PVNS in a nondomestic ungulate.
AB - A 17-yr-old, female, captive-born reticulated giraffe (Giraffa camelopardalis) presented with acute-onset lameness of the right metacarpophalangeal (fetlock) joint. Despite multiple courses of treatment, the lameness and swelling progressively worsened over a 3.5-yr period, and the giraffe was euthanized. At necropsy, gross and microscopic changes in the right, front fetlock and associated flexor tendon sheath included villous synovial hyperplasia and the formation of discrete pigmented nodules within synovial membranes. Histologically, the nodules were composed of abundant, fibrous connective tissue with heavy macrophage infiltration, hemosiderin deposition, and distinctive, multinucleated cells that resembled osteoclasts. These findings were consistent with pigmented villonodular synovitis (PVNS), a rare condition affecting both humans and animals. Although the pathophysiology of PVNS is poorly understood, lesions exhibit features of both neoplastic and reactive inflammatory processes. This case report represents, to the authors' knowledge, the first description of PVNS in a nondomestic ungulate.
KW - Giraffa camelopardalis
KW - PVNS
KW - metacarpophalangeal joint
KW - pigmented villonodular synovitis
KW - reticulated giraffe
KW - tenosynovitis
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UR - http://www.scopus.com/inward/citedby.url?scp=85026553270&partnerID=8YFLogxK
U2 - 10.1638/2016-0133R.1
DO - 10.1638/2016-0133R.1
M3 - Article
C2 - 28749260
AN - SCOPUS:85026553270
SN - 1042-7260
VL - 48
SP - 573
EP - 577
JO - Journal of Zoo and Wildlife Medicine
JF - Journal of Zoo and Wildlife Medicine
IS - 2
ER -