PIGMENTED VILLONODULAR SYNOVITIS in A RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS)

Elizabeth A. Ihms, Anne Rivas, Ellen Bronson, Lisa Mangus

Research output: Contribution to journalArticle

Abstract

A 17-yr-old, female, captive-born reticulated giraffe (Giraffa camelopardalis) presented with acute-onset lameness of the right metacarpophalangeal (fetlock) joint. Despite multiple courses of treatment, the lameness and swelling progressively worsened over a 3.5-yr period, and the giraffe was euthanized. At necropsy, gross and microscopic changes in the right, front fetlock and associated flexor tendon sheath included villous synovial hyperplasia and the formation of discrete pigmented nodules within synovial membranes. Histologically, the nodules were composed of abundant, fibrous connective tissue with heavy macrophage infiltration, hemosiderin deposition, and distinctive, multinucleated cells that resembled osteoclasts. These findings were consistent with pigmented villonodular synovitis (PVNS), a rare condition affecting both humans and animals. Although the pathophysiology of PVNS is poorly understood, lesions exhibit features of both neoplastic and reactive inflammatory processes. This case report represents, to the authors' knowledge, the first description of PVNS in a nondomestic ungulate.

Original languageEnglish (US)
Pages (from-to)573-577
Number of pages5
JournalJournal of Zoo and Wildlife Medicine
Volume48
Issue number2
DOIs
StatePublished - Jun 1 2017

Fingerprint

Pigmented Villonodular Synovitis
Giraffa camelopardalis
synovitis
lameness
hemosiderin
Hemosiderin
Metacarpophalangeal Joint
osteoclasts
Synovial Membrane
Osteoclasts
tendons
pathophysiology
ungulates
hyperplasia
joints (animal)
lesions (animal)
connective tissues
Tendons
Connective Tissue
Hyperplasia

Keywords

  • Giraffa camelopardalis
  • metacarpophalangeal joint
  • pigmented villonodular synovitis
  • PVNS
  • reticulated giraffe
  • tenosynovitis

ASJC Scopus subject areas

  • Medicine(all)
  • Animal Science and Zoology
  • veterinary(all)

Cite this

PIGMENTED VILLONODULAR SYNOVITIS in A RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS). / Ihms, Elizabeth A.; Rivas, Anne; Bronson, Ellen; Mangus, Lisa.

In: Journal of Zoo and Wildlife Medicine, Vol. 48, No. 2, 01.06.2017, p. 573-577.

Research output: Contribution to journalArticle

Ihms, Elizabeth A. ; Rivas, Anne ; Bronson, Ellen ; Mangus, Lisa. / PIGMENTED VILLONODULAR SYNOVITIS in A RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS). In: Journal of Zoo and Wildlife Medicine. 2017 ; Vol. 48, No. 2. pp. 573-577.
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