Pigmented ganglioglioma in a patient with chronic epilepsy and cortical dysplasia

Mena G. Kerolus, Robert G. Kellogg, Jorge Novo, Leonidas D. Arvanitis, Richard W. Byrne

Research output: Contribution to journalReview articlepeer-review


We report a rare case of a 22-year-old woman with biopsy-proven pigmented ganglioglioma. The patient initially underwent a right temporal lobectomy for intractable seizures at the age of 9 and remained seizure free for several years but subsequently developed complex partial seizures. Due to enhancement of a left mesial occipital lesion on preoperative MRI of the brain, the patient underwent a left subdural electrode placement and simultaneous biopsy of the left mesial occipital lesion. Biopsy results revealed a rare pigmented ganglioglioma, World Health Organization Grade I. The seizure focus was identified in the left mesial occipital lobe and the patient underwent tumor resection. An extensive literature search revealed that our patient is the fourth case of pigmented ganglioglioma described in the literature and was positive for BRAF V600E mutation by molecular studies.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalJournal of Clinical Neuroscience
StatePublished - Feb 1 2016


  • Chronic epilepsy
  • Cortical dysplasia
  • Melanocytic melanogenesis
  • Neuromelanin
  • Pigmented ganglioglioma

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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