PI3 Kinase Activation and Response to Trastuzumab Therapy: What's neu with Herceptin Resistance?

Ben Ho Park, Nancy E. Davidson

Research output: Contribution to journalShort surveypeer-review

Abstract

Trastuzumab is an established therapy for women with breast cancers that overexpress HER2. Despite its proven benefit in treating breast cancer, not all women derive benefit from this monoclonal antibody, and resistant disease can develop. In this issue of Cancer Cell, Berns et al. present evidence that activation of the PI3 kinase pathway, either via loss of the tumor suppressor PTEN or through oncogenic stimulation of PIK3CA, can mediate trastuzumab resistance. This study extends important work of others and forms the rationale for future investigations combining inhibitors of the PI3 kinase pathway in conjunction with trastuzumab therapy.

Original languageEnglish (US)
Pages (from-to)297-299
Number of pages3
JournalCancer cell
Volume12
Issue number4
DOIs
StatePublished - Oct 16 2007

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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