PI-RADS committee position on MRI without contrast medium in biopsy-naive men with suspected prostate cancer: narrative review

Ivo G. Schoots, Jelle O. Barentsz, Leonardo K. Bittencourt, Masoom A. Haider, Katarzyna J. Macura, Daniel J.A. Margolis, Caroline M. Moore, Aytekin Oto, Valeria Panebianco, Mohummad M. Siddiqui, Clare Tempany, Baris Turkbey, Geert M. Villeirs, Jeffrey C. Weinreb, Anwar R. Padhani

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


The steadily increasing demand for diagnostic prostate MRI has led to concerns regarding the lack of access to and the availability of qualified MRI scanners and sufficiently experienced radiologists, radiographers, and technologists to meet the demand. Solutions must enhance operational benefits without compromising diagnostic performance, quality, and delivery of service. Solutions should also mitigate risks such as decreased reader confidence and referrer engagement. One approach may be the implementation of MRI without the use gadolinium-based contrast medium (biparametric MRI), but only if certain prerequisites such as high-quality imaging, expert interpretation quality, and availability of patient recall or on-table monitoring are mandated. Alternatively, or in combination, a clinical risk-based approach could be used for protocol selection, specifically, which biopsy-naive men need MRI with contrast medium (multiparametric MRI). There is a need for prospective studies in which biopsy decisions are made according to MRI without contrast enhancement. Such studies must define clinical and operational benefits and identify which patient groups can be scanned successfully without contrast enhancement. These higher-quality data are needed before the Prostate Imaging Reporting and Data System (PI-RADS) Committee can make evidence-based recommendations about MRI without contrast enhancement as an initial diagnostic approach for prostate cancer workup.

Original languageEnglish (US)
Pages (from-to)3-19
Number of pages17
JournalAmerican Journal of Roentgenology
Issue number1
StatePublished - Jan 2021


  • Biopsy avoidance
  • Biparametric MRI
  • Dynamic contrast-enhanced
  • Gadolinium contrast medium
  • MRI
  • Multiparametric MRI
  • Prostate cancer
  • Risk stratification
  • Unenhanced MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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