Phytohemagglutinin induced proliferation of guinea pig thymus derived lymphocytes. II. Accessory cell function

J. J. Ellner, P. E. Lipsky, A. S. Rosenthal

Research output: Contribution to journalArticlepeer-review

Abstract

Accessory cell participation in PHA induced thymus derived lymphocyte DNA synthesis encompasses two distinct functions. The first consists of maintenance of the functional integrity of resting lymphocytes, and the second involves the direct induction and/or support of T cell proliferation in response to this mitogen. Whereas the reducing agent 2 mercaptoethanol can support an Mphi depleted population of resting lymphocytes so that the latent biologic activity is maintained, it is not itself sufficient to allow the induction of lymphocyte proliferation in response to PHA. This latter function requires intact accessory cells.

Original languageEnglish (US)
Pages (from-to)876-880
Number of pages5
JournalJournal of Immunology
Volume116
Issue number3
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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