Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism

Hyeong Kyu Park, Rexford S. Ahima

Research output: Contribution to journalReview article

Abstract

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues. Leptin administration has been shown to restore metabolic and neuroendocrine abnormalities in individuals with leptin-deficient states, including hypothalamic amenorrhea and lipoatrophy. In contrast, obese individuals are resistant to leptin. Recombinant leptin is beneficial in patients with congenital leptin deficiency or generalized lipodystrophy. However, further research on molecular mediators of leptin resistance is needed for the development of targeted leptin sensitizing therapies for obesity and related metabolic diseases.

Original languageEnglish (US)
Pages (from-to)24-34
Number of pages11
JournalMetabolism: clinical and experimental
Volume64
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Energy homeostasis
  • Hypothalamus
  • Leptin
  • Metabolism
  • Obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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