Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

M. Tschöp; T. R. Castañeda; H. G. Joost; C. Thöne-Reineke; S. Ortmann; S. Klaus; M. M. Hagan; P. C. Chandler; K. D. Oswald; S. C. Benoit; R. J. Seeley; K. P. Kinzig; T. H. Moran; A. G. Beck-sickinger; N. Koglin; R. J. Rodgers; J. E. Blundell; Y. Ishii; A. H. Beattie; P. Holch; D. B. Allison; K. Raun; K. Madsen; B. S. Wulff; C. E. Stidsen; M. Birringer; O. J. Kreuzer; M. Schindler; K. Arndt; K. Rudolf; M. Mark; X. Y. Deng; D. C. Whitcomb; H. Halem; J. Taylor; J. Dong; R. Datta; M. Culler; S. Craney; D. Flora; D. Smiley; M. L. Heiman

doi:10.1038/nature02665

Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

M. Tschöp, T. R. Castañeda, H. G. Joost, C. Thöne-Reineke, S. Ortmann, S. Klaus, M. M. Hagan, P. C. Chandler, K. D. Oswald, S. C. Benoit, R. J. Seeley, K. P. Kinzig, T. H. Moran, A. G. Beck-sickinger, N. Koglin, R. J. Rodgers, J. E. Blundell, Y. Ishii, A. H. Beattie, P. HolchD. B. Allison, K. Raun, K. Madsen, B. S. Wulff, C. E. Stidsen, M. Birringer, O. J. Kreuzer, M. Schindler, K. Arndt, K. Rudolf, M. Mark, X. Y. Deng, D. C. Whitcomb, H. Halem, J. Taylor, J. Dong, R. Datta, M. Culler, S. Craney, D. Flora, D. Smiley, M. L. Heiman

Research output: Contribution to journal › Comment/debate › peer-review

187 Scopus citations

Abstract

Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.

Original language	English (US)
Pages (from-to)	1 p following 165; discussion 2 p following 165
Journal	Nature
Volume	430
Issue number	6996
DOIs	https://doi.org/10.1038/nature02665
State	Published - Jul 8 2004
Externally published	Yes

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Tschöp, M., Castañeda, T. R., Joost, H. G., Thöne-Reineke, C., Ortmann, S., Klaus, S., Hagan, M. M., Chandler, P. C., Oswald, K. D., Benoit, S. C., Seeley, R. J., Kinzig, K. P., Moran, T. H., Beck-sickinger, A. G., Koglin, N., Rodgers, R. J., Blundell, J. E., Ishii, Y., Beattie, A. H., ... Heiman, M. L. (2004). Physiology: does gut hormone PYY3-36 decrease food intake in rodents? Nature, 430(6996), 1 p following 165; discussion 2 p following 165. https://doi.org/10.1038/nature02665

Tschöp, M, Castañeda, TR, Joost, HG, Thöne-Reineke, C, Ortmann, S, Klaus, S, Hagan, MM, Chandler, PC, Oswald, KD, Benoit, SC, Seeley, RJ, Kinzig, KP, Moran, TH, Beck-sickinger, AG, Koglin, N, Rodgers, RJ, Blundell, JE, Ishii, Y, Beattie, AH, Holch, P, Allison, DB, Raun, K, Madsen, K, Wulff, BS, Stidsen, CE, Birringer, M, Kreuzer, OJ, Schindler, M, Arndt, K, Rudolf, K, Mark, M, Deng, XY, Whitcomb, DC, Halem, H, Taylor, J, Dong, J, Datta, R, Culler, M, Craney, S, Flora, D, Smiley, D & Heiman, ML 2004, 'Physiology: does gut hormone PYY3-36 decrease food intake in rodents?', Nature, vol. 430, no. 6996, pp. 1 p following 165; discussion 2 p following 165. https://doi.org/10.1038/nature02665

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title = "Physiology: does gut hormone PYY3-36 decrease food intake in rodents?",

abstract = "Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.",

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AU - Castañeda, T. R.

AU - Joost, H. G.

AU - Thöne-Reineke, C.

AU - Ortmann, S.

AU - Klaus, S.

AU - Hagan, M. M.

AU - Chandler, P. C.

AU - Oswald, K. D.

AU - Benoit, S. C.

AU - Seeley, R. J.

AU - Kinzig, K. P.

AU - Moran, T. H.

AU - Beck-sickinger, A. G.

AU - Koglin, N.

AU - Rodgers, R. J.

AU - Blundell, J. E.

AU - Ishii, Y.

AU - Beattie, A. H.

AU - Holch, P.

AU - Allison, D. B.

AU - Raun, K.

AU - Madsen, K.

AU - Wulff, B. S.

AU - Stidsen, C. E.

AU - Birringer, M.

AU - Kreuzer, O. J.

AU - Schindler, M.

AU - Arndt, K.

AU - Rudolf, K.

AU - Mark, M.

AU - Deng, X. Y.

AU - Whitcomb, D. C.

AU - Halem, H.

AU - Taylor, J.

AU - Dong, J.

AU - Datta, R.

AU - Culler, M.

AU - Craney, S.

AU - Flora, D.

AU - Smiley, D.

AU - Heiman, M. L.

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Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

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