Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

M. Tschöp, T. R. Castañeda, H. G. Joost, C. Thöne-Reineke, S. Ortmann, S. Klaus, M. M. Hagan, P. C. Chandler, K. D. Oswald, S. C. Benoit, R. J. Seeley, K. P. Kinzig, T. H. Moran, A. G. Beck-sickinger, N. Koglin, R. J. Rodgers, J. E. Blundell, Y. Ishii, A. H. Beattie, P. HolchD. B. Allison, K. Raun, K. Madsen, B. S. Wulff, C. E. Stidsen, M. Birringer, O. J. Kreuzer, M. Schindler, K. Arndt, K. Rudolf, M. Mark, X. Y. Deng, D. C. Whitcomb, H. Halem, J. Taylor, J. Dong, R. Datta, M. Culler, S. Craney, D. Flora, D. Smiley, M. L. Heiman

Research output: Contribution to journalComment/debatepeer-review

Abstract

Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.

Original languageEnglish (US)
Pages (from-to)1 p following 165; discussion 2 p following 165
JournalNature
Volume430
Issue number6996
DOIs
StatePublished - Jul 8 2004

ASJC Scopus subject areas

  • General

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