Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

M. Tschöp, T. R. Castañeda, H. G. Joost, C. Thöne-Reineke, S. Ortmann, S. Klaus, M. M. Hagan, P. C. Chandler, K. D. Oswald, S. C. Benoit, R. J. Seeley, K. P. Kinzig, Timothy H Moran, A. G. Beck-sickinger, N. Koglin, R. J. Rodgers, J. E. Blundell, Y. Ishii, A. H. Beattie, P. HolchD. B. Allison, K. Raun, K. Madsen, B. S. Wulff, C. E. Stidsen, M. Birringer, O. J. Kreuzer, M. Schindler, K. Arndt, K. Rudolf, M. Mark, X. Y. Deng, D. C. Withcomb, H. Halem, J. Taylor, J. Dong, R. Datta, M. Culler, S. Craney, D. Flora, D. Smiley, M. L. Heiman

Research output: Contribution to journalArticle

Abstract

Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.

Original languageEnglish (US)
JournalNature
Volume430
Issue number6996
StatePublished - Jul 8 2004
Externally publishedYes

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Rodentia
Obesity
Eating
Anti-Obesity Agents
Hormones
Peptide Hormones
Weight Gain
Body Weight
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Tschöp, M., Castañeda, T. R., Joost, H. G., Thöne-Reineke, C., Ortmann, S., Klaus, S., ... Heiman, M. L. (2004). Physiology: does gut hormone PYY3-36 decrease food intake in rodents? Nature, 430(6996).

Physiology : does gut hormone PYY3-36 decrease food intake in rodents? / Tschöp, M.; Castañeda, T. R.; Joost, H. G.; Thöne-Reineke, C.; Ortmann, S.; Klaus, S.; Hagan, M. M.; Chandler, P. C.; Oswald, K. D.; Benoit, S. C.; Seeley, R. J.; Kinzig, K. P.; Moran, Timothy H; Beck-sickinger, A. G.; Koglin, N.; Rodgers, R. J.; Blundell, J. E.; Ishii, Y.; Beattie, A. H.; Holch, P.; Allison, D. B.; Raun, K.; Madsen, K.; Wulff, B. S.; Stidsen, C. E.; Birringer, M.; Kreuzer, O. J.; Schindler, M.; Arndt, K.; Rudolf, K.; Mark, M.; Deng, X. Y.; Withcomb, D. C.; Halem, H.; Taylor, J.; Dong, J.; Datta, R.; Culler, M.; Craney, S.; Flora, D.; Smiley, D.; Heiman, M. L.

In: Nature, Vol. 430, No. 6996, 08.07.2004.

Research output: Contribution to journalArticle

Tschöp, M, Castañeda, TR, Joost, HG, Thöne-Reineke, C, Ortmann, S, Klaus, S, Hagan, MM, Chandler, PC, Oswald, KD, Benoit, SC, Seeley, RJ, Kinzig, KP, Moran, TH, Beck-sickinger, AG, Koglin, N, Rodgers, RJ, Blundell, JE, Ishii, Y, Beattie, AH, Holch, P, Allison, DB, Raun, K, Madsen, K, Wulff, BS, Stidsen, CE, Birringer, M, Kreuzer, OJ, Schindler, M, Arndt, K, Rudolf, K, Mark, M, Deng, XY, Withcomb, DC, Halem, H, Taylor, J, Dong, J, Datta, R, Culler, M, Craney, S, Flora, D, Smiley, D & Heiman, ML 2004, 'Physiology: does gut hormone PYY3-36 decrease food intake in rodents?', Nature, vol. 430, no. 6996.
Tschöp M, Castañeda TR, Joost HG, Thöne-Reineke C, Ortmann S, Klaus S et al. Physiology: does gut hormone PYY3-36 decrease food intake in rodents? Nature. 2004 Jul 8;430(6996).
Tschöp, M. ; Castañeda, T. R. ; Joost, H. G. ; Thöne-Reineke, C. ; Ortmann, S. ; Klaus, S. ; Hagan, M. M. ; Chandler, P. C. ; Oswald, K. D. ; Benoit, S. C. ; Seeley, R. J. ; Kinzig, K. P. ; Moran, Timothy H ; Beck-sickinger, A. G. ; Koglin, N. ; Rodgers, R. J. ; Blundell, J. E. ; Ishii, Y. ; Beattie, A. H. ; Holch, P. ; Allison, D. B. ; Raun, K. ; Madsen, K. ; Wulff, B. S. ; Stidsen, C. E. ; Birringer, M. ; Kreuzer, O. J. ; Schindler, M. ; Arndt, K. ; Rudolf, K. ; Mark, M. ; Deng, X. Y. ; Withcomb, D. C. ; Halem, H. ; Taylor, J. ; Dong, J. ; Datta, R. ; Culler, M. ; Craney, S. ; Flora, D. ; Smiley, D. ; Heiman, M. L. / Physiology : does gut hormone PYY3-36 decrease food intake in rodents?. In: Nature. 2004 ; Vol. 430, No. 6996.
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AU - Beattie, A. H.

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AU - Mark, M.

AU - Deng, X. Y.

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