Physiological functions of transient receptor potential channels in pulmonary arterial smooth muscle cells

Xiao Ru Yang, Mo Jun Lin, James S.K. Sham

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The transient receptor potential (TRP) gene superfamily, which consists of 7 subfamilies with at least 28 mammalian homologues, is known to encode a wide variety of cation channels with diverse biophysical properties, activation mechanisms, and physiological functions. Recent studies have identified multiple TRP channel subtypes, belonging to the canonical (TRPC), melastatin-related (TRPM), and vanilloid-related (TRPV) subfamilies, in pulmonary arterial smooth muscle cells (PASMCs). They operate as specific Ca2+ pathways responsive to stimuli, including Ca2+ store depletion, receptor activation, reactive oxygen species, growth factors, and mechanical stress. Increasing evidence suggests that these channels play crucial roles in agonist-induced pulmonary vasoconstriction, hypoxic pulmonary vasoconstriction, smooth muscle cell proliferation, vascular remodeling, and pulmonary arterial hypertension. This chapter highlighted and discussed these putative physiological functions of TRP channels in pulmonary vasculatures. Since Ca 2+ ions regulate many cellular processes via specific Ca2+ signals, future investigations of these novel channels will likely uncover more important regulatory mechanisms of pulmonary vascular functions in health and in disease states.

Original languageEnglish (US)
Title of host publicationMembrane Receptors, Channels and Transporters in Pulmonary Circulation
EditorsJ.X.J Yuan, J.P.T. Ward
Pages109-122
Number of pages14
DOIs
StatePublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume661
ISSN (Print)0065-2598

Keywords

  • Hypoxia
  • Pulmonary hypertension
  • Receptor operated calcium channels
  • Store-operated calcium channels
  • TRP channels

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Yang, X. R., Lin, M. J., & Sham, J. S. K. (2010). Physiological functions of transient receptor potential channels in pulmonary arterial smooth muscle cells. In J. X. J. Yuan, & J. P. T. Ward (Eds.), Membrane Receptors, Channels and Transporters in Pulmonary Circulation (pp. 109-122). (Advances in Experimental Medicine and Biology; Vol. 661). https://doi.org/10.1007/978-1-60761-500-2_7