TY - GEN
T1 - Physiological functions of transient receptor potential channels in pulmonary arterial smooth muscle cells
AU - Yang, Xiao Ru
AU - Lin, Mo Jun
AU - Sham, James S.K.
PY - 2010
Y1 - 2010
N2 - The transient receptor potential (TRP) gene superfamily, which consists of 7 subfamilies with at least 28 mammalian homologues, is known to encode a wide variety of cation channels with diverse biophysical properties, activation mechanisms, and physiological functions. Recent studies have identified multiple TRP channel subtypes, belonging to the canonical (TRPC), melastatin-related (TRPM), and vanilloid-related (TRPV) subfamilies, in pulmonary arterial smooth muscle cells (PASMCs). They operate as specific Ca2+ pathways responsive to stimuli, including Ca2+ store depletion, receptor activation, reactive oxygen species, growth factors, and mechanical stress. Increasing evidence suggests that these channels play crucial roles in agonist-induced pulmonary vasoconstriction, hypoxic pulmonary vasoconstriction, smooth muscle cell proliferation, vascular remodeling, and pulmonary arterial hypertension. This chapter highlighted and discussed these putative physiological functions of TRP channels in pulmonary vasculatures. Since Ca 2+ ions regulate many cellular processes via specific Ca2+ signals, future investigations of these novel channels will likely uncover more important regulatory mechanisms of pulmonary vascular functions in health and in disease states.
AB - The transient receptor potential (TRP) gene superfamily, which consists of 7 subfamilies with at least 28 mammalian homologues, is known to encode a wide variety of cation channels with diverse biophysical properties, activation mechanisms, and physiological functions. Recent studies have identified multiple TRP channel subtypes, belonging to the canonical (TRPC), melastatin-related (TRPM), and vanilloid-related (TRPV) subfamilies, in pulmonary arterial smooth muscle cells (PASMCs). They operate as specific Ca2+ pathways responsive to stimuli, including Ca2+ store depletion, receptor activation, reactive oxygen species, growth factors, and mechanical stress. Increasing evidence suggests that these channels play crucial roles in agonist-induced pulmonary vasoconstriction, hypoxic pulmonary vasoconstriction, smooth muscle cell proliferation, vascular remodeling, and pulmonary arterial hypertension. This chapter highlighted and discussed these putative physiological functions of TRP channels in pulmonary vasculatures. Since Ca 2+ ions regulate many cellular processes via specific Ca2+ signals, future investigations of these novel channels will likely uncover more important regulatory mechanisms of pulmonary vascular functions in health and in disease states.
KW - Hypoxia
KW - Pulmonary hypertension
KW - Receptor operated calcium channels
KW - Store-operated calcium channels
KW - TRP channels
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U2 - 10.1007/978-1-60761-500-2_7
DO - 10.1007/978-1-60761-500-2_7
M3 - Conference contribution
C2 - 20204726
AN - SCOPUS:77951230045
SN - 9781607614999
T3 - Advances in Experimental Medicine and Biology
SP - 109
EP - 122
BT - Membrane Receptors, Channels and Transporters in Pulmonary Circulation
A2 - Yuan, J.X.J
A2 - Ward, J.P.T.
ER -