Physiological functions for brain NF-κB

Mollie K. Meffert, David Baltimore

Research output: Contribution to journalReview articlepeer-review


Members of the nuclear factor κB (NF-κB) family of transcription factors are activated within the CNS in pathological settings of apoptosis and neurological disease. Recent work using several model systems provides accumulating evidence that these transcription factors also participate in the regulation of neuronal activity-dependent transcription and behavior under physiological conditions. This review highlights advances in our understanding of the mechanisms of Ca 2+-responsive activation and synaptic signaling to the nucleus by NF-κB transcription factors within the CNS, and the relevance of this transcription factor family for learning and memory.

Original languageEnglish (US)
Pages (from-to)37-43
Number of pages7
JournalTrends in neurosciences
Issue number1
StatePublished - Jan 2005
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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