Physiological effects of focused ultrasound pulses on mammalian CNS tissue in an in-vitro preparation

C. S. Georgiades, P. C. Rinaldi, J. P. Jones, L. Price, F. Reines

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have investigated the effects of pulsed and highly focused ultrasound on the physiology of 500 micron thick hippocampal slices obtained from 50 male, 120 gram Sprague-Dawley rats. During the study the slices were kept alive in a special in-vitro preparation. We compared the magnitude and latency of the control evoked responses to those of the responses recorded during ultrasound irradiation. Comparisons were made for both the orthodromic and antidromic population responses. For all studies, a highly focused pulsed ultrasonic beam was used with a center frequency of 5 MHz and an intensity (SPTA) of 52 W/cm2. Significant changes in both the magnitude and the stimulus-response delay were observed. Full recovery was observed when the ultrasound was removed. In addition, temperature effects could be rejected as the sole mechanism producing such changes.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
PublisherIEEE
Pages1833-1836
Number of pages4
Volume3
Publication statusPublished - 1994
Externally publishedYes
EventProceedings of the 1994 IEEE Ultrasonics Symposium. Part 1 (of 3) - Cannes, Fr
Duration: Nov 1 1994Nov 4 1994

Other

OtherProceedings of the 1994 IEEE Ultrasonics Symposium. Part 1 (of 3)
CityCannes, Fr
Period11/1/9411/4/94

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Georgiades, C. S., Rinaldi, P. C., Jones, J. P., Price, L., & Reines, F. (1994). Physiological effects of focused ultrasound pulses on mammalian CNS tissue in an in-vitro preparation. In Proceedings of the IEEE Ultrasonics Symposium (Vol. 3, pp. 1833-1836). IEEE.