TY - JOUR
T1 - Physiological Changes from Violence-Induced Stress and Trauma Enhance HIV Susceptibility Among Women
AU - Tsuyuki, Kiyomi
AU - Cimino, Andrea N.
AU - Holliday, Charvonne N.
AU - Campbell, Jacquelyn C.
AU - Al-Alusi, Noor A.
AU - Stockman, Jamila K.
N1 - Funding Information:
Funding Information This research was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD077891 - support for J.K. Stockman, J.C. Campbell, A.N. Cimino, C.N. Holliday, and K. Tsuyuki; R01HD077891-04S1 – support for K. Tsuyuki; T32HD064428 – J. Campbell, C.N. Holliday and A. N. Cimino), the National Institute of Alcoholism and Alcohol Abuse (K01AA025009 - K. Tsuyuki), the National Institute of Drug Abuse (K01DA031593 - J.K. Stockman; T32DA023356 - K. Tsuyuki), the National Institute on Minority Health and Health Disparities (L60MD003701 - J.K. Stockman; L60MD011184-K. Tsuyuki; 1L60MD012089-01 – C.N. Holliday), the Health Resources and Services Administration (T76MC00003 – C.N. Holliday), Johns Hopkins University Center for AIDS Research (P30AI094189), and the UCSD Center for AIDS Research (P30AI036214).
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/2/15
Y1 - 2019/2/15
N2 - Purpose of Review: This theoretical review identifies physiological mechanisms by which violence against women (VAW) may increase women’s susceptibility to HIV through trauma, stress, and immune dysfunction. Recent Findings: Research documents systemic and local immune responses are related to stress and trauma from abuse across the life course (i.e., childhood, IPV, adulthood re-victimization). Findings are interpreted within a theoretical framework grounded in the Social Stress Theory and the concept of toxic stress, and highlight the current state of the science connecting: (1) VAW to the physiological stress response and immune dysfunction, and (2) the physiological stress response and inflammation to HIV susceptibility and infection in the female reproductive tract. Summary: Despite a dearth of research in human subjects, evidence suggests that VAW plays a significant role in creating a physiological environment conducive to HIV infection. We conclude with a discussion of promising future steps for this line of research.
AB - Purpose of Review: This theoretical review identifies physiological mechanisms by which violence against women (VAW) may increase women’s susceptibility to HIV through trauma, stress, and immune dysfunction. Recent Findings: Research documents systemic and local immune responses are related to stress and trauma from abuse across the life course (i.e., childhood, IPV, adulthood re-victimization). Findings are interpreted within a theoretical framework grounded in the Social Stress Theory and the concept of toxic stress, and highlight the current state of the science connecting: (1) VAW to the physiological stress response and immune dysfunction, and (2) the physiological stress response and inflammation to HIV susceptibility and infection in the female reproductive tract. Summary: Despite a dearth of research in human subjects, evidence suggests that VAW plays a significant role in creating a physiological environment conducive to HIV infection. We conclude with a discussion of promising future steps for this line of research.
KW - HIV
KW - Immune dysfunction
KW - Physiological stress response
KW - Trauma
KW - Violence against women
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U2 - 10.1007/s11904-019-00435-8
DO - 10.1007/s11904-019-00435-8
M3 - Review article
C2 - 30762216
AN - SCOPUS:85061700828
VL - 16
SP - 57
EP - 65
JO - Current HIV/AIDS Reports
JF - Current HIV/AIDS Reports
SN - 1548-3568
IS - 1
ER -