Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts

R. M. Judd, C. H. Lugo-Olivieri, M. Arai, T. Kondo, P. Croisille, Joao Lima, V. Mohan, Lewis Becker, Elias Zerhouni

Research output: Contribution to journalArticle

Abstract

Background: Contrast-enhanced fast magnetic resonance (MR) images of acute, reperfused human infarcts demonstrate regimes of hypoenhancement and hyperenhancement. The relations between the spatial extent and time course of these enhancement patterns to myocardial risk, infarct, and no-reflow regions have not been well characterized. Methods and Results: The proximal left anterior descending coronary artery was occluded in 11 closed-chest dogs for 90 minutes followed by 2 days of reperfusion. Regional blood flow was determined by use of radioactive microspheres. The animals were studied at the 2-day time point with contrast enhanced fast MRI (Signa 1.5 T. General Electric). Thioflavin-S was administered to demarcate no-reflow regions. The hearts were then excised, sectioned into five base-to-apex slices, stained with 2,3,5-triphenyltetrazolium chloride (TTC), and photographed under room light (for ITC) and ultraviolet light (for thioflavin). The spatial extents of thioflavin-negative, TTC-negative, and risk regions were compared planimetrically with MRI hypoenhanced and hyperenhanced regions. The spatial locations of subendocardial hypoenhancement in MR images correlated closely with those of thioflavin-negative regions. Microsphere blood flow in these regions was significantly reduced compared with remote regions (0.37 ± 0.09 versus 0.88 ± 0.10 mL/min per gram, respectively, P

Original languageEnglish (US)
Pages (from-to)1902-1910
Number of pages9
JournalCirculation
Volume92
Issue number7
StatePublished - 1995

Fingerprint

Microspheres
Canidae
Magnetic Resonance Spectroscopy
Regional Blood Flow
Ultraviolet Rays
Reperfusion
Coronary Vessels
Thorax
Myocardial Infarction
Dogs
Light
triphenyltetrazolium
thioflavin T

Keywords

  • contrast media
  • magnetic resonance imaging
  • myocardial infarction
  • perfusion
  • reperfusion

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts. / Judd, R. M.; Lugo-Olivieri, C. H.; Arai, M.; Kondo, T.; Croisille, P.; Lima, Joao; Mohan, V.; Becker, Lewis; Zerhouni, Elias.

In: Circulation, Vol. 92, No. 7, 1995, p. 1902-1910.

Research output: Contribution to journalArticle

Judd, R. M. ; Lugo-Olivieri, C. H. ; Arai, M. ; Kondo, T. ; Croisille, P. ; Lima, Joao ; Mohan, V. ; Becker, Lewis ; Zerhouni, Elias. / Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts. In: Circulation. 1995 ; Vol. 92, No. 7. pp. 1902-1910.
@article{35a7058528b949afa9aa820f8d60dab2,
title = "Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts",
abstract = "Background: Contrast-enhanced fast magnetic resonance (MR) images of acute, reperfused human infarcts demonstrate regimes of hypoenhancement and hyperenhancement. The relations between the spatial extent and time course of these enhancement patterns to myocardial risk, infarct, and no-reflow regions have not been well characterized. Methods and Results: The proximal left anterior descending coronary artery was occluded in 11 closed-chest dogs for 90 minutes followed by 2 days of reperfusion. Regional blood flow was determined by use of radioactive microspheres. The animals were studied at the 2-day time point with contrast enhanced fast MRI (Signa 1.5 T. General Electric). Thioflavin-S was administered to demarcate no-reflow regions. The hearts were then excised, sectioned into five base-to-apex slices, stained with 2,3,5-triphenyltetrazolium chloride (TTC), and photographed under room light (for ITC) and ultraviolet light (for thioflavin). The spatial extents of thioflavin-negative, TTC-negative, and risk regions were compared planimetrically with MRI hypoenhanced and hyperenhanced regions. The spatial locations of subendocardial hypoenhancement in MR images correlated closely with those of thioflavin-negative regions. Microsphere blood flow in these regions was significantly reduced compared with remote regions (0.37 ± 0.09 versus 0.88 ± 0.10 mL/min per gram, respectively, P",
keywords = "contrast media, magnetic resonance imaging, myocardial infarction, perfusion, reperfusion",
author = "Judd, {R. M.} and Lugo-Olivieri, {C. H.} and M. Arai and T. Kondo and P. Croisille and Joao Lima and V. Mohan and Lewis Becker and Elias Zerhouni",
year = "1995",
language = "English (US)",
volume = "92",
pages = "1902--1910",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts

AU - Judd, R. M.

AU - Lugo-Olivieri, C. H.

AU - Arai, M.

AU - Kondo, T.

AU - Croisille, P.

AU - Lima, Joao

AU - Mohan, V.

AU - Becker, Lewis

AU - Zerhouni, Elias

PY - 1995

Y1 - 1995

N2 - Background: Contrast-enhanced fast magnetic resonance (MR) images of acute, reperfused human infarcts demonstrate regimes of hypoenhancement and hyperenhancement. The relations between the spatial extent and time course of these enhancement patterns to myocardial risk, infarct, and no-reflow regions have not been well characterized. Methods and Results: The proximal left anterior descending coronary artery was occluded in 11 closed-chest dogs for 90 minutes followed by 2 days of reperfusion. Regional blood flow was determined by use of radioactive microspheres. The animals were studied at the 2-day time point with contrast enhanced fast MRI (Signa 1.5 T. General Electric). Thioflavin-S was administered to demarcate no-reflow regions. The hearts were then excised, sectioned into five base-to-apex slices, stained with 2,3,5-triphenyltetrazolium chloride (TTC), and photographed under room light (for ITC) and ultraviolet light (for thioflavin). The spatial extents of thioflavin-negative, TTC-negative, and risk regions were compared planimetrically with MRI hypoenhanced and hyperenhanced regions. The spatial locations of subendocardial hypoenhancement in MR images correlated closely with those of thioflavin-negative regions. Microsphere blood flow in these regions was significantly reduced compared with remote regions (0.37 ± 0.09 versus 0.88 ± 0.10 mL/min per gram, respectively, P

AB - Background: Contrast-enhanced fast magnetic resonance (MR) images of acute, reperfused human infarcts demonstrate regimes of hypoenhancement and hyperenhancement. The relations between the spatial extent and time course of these enhancement patterns to myocardial risk, infarct, and no-reflow regions have not been well characterized. Methods and Results: The proximal left anterior descending coronary artery was occluded in 11 closed-chest dogs for 90 minutes followed by 2 days of reperfusion. Regional blood flow was determined by use of radioactive microspheres. The animals were studied at the 2-day time point with contrast enhanced fast MRI (Signa 1.5 T. General Electric). Thioflavin-S was administered to demarcate no-reflow regions. The hearts were then excised, sectioned into five base-to-apex slices, stained with 2,3,5-triphenyltetrazolium chloride (TTC), and photographed under room light (for ITC) and ultraviolet light (for thioflavin). The spatial extents of thioflavin-negative, TTC-negative, and risk regions were compared planimetrically with MRI hypoenhanced and hyperenhanced regions. The spatial locations of subendocardial hypoenhancement in MR images correlated closely with those of thioflavin-negative regions. Microsphere blood flow in these regions was significantly reduced compared with remote regions (0.37 ± 0.09 versus 0.88 ± 0.10 mL/min per gram, respectively, P

KW - contrast media

KW - magnetic resonance imaging

KW - myocardial infarction

KW - perfusion

KW - reperfusion

UR - http://www.scopus.com/inward/record.url?scp=0029129605&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029129605&partnerID=8YFLogxK

M3 - Article

C2 - 7671375

AN - SCOPUS:0029129605

VL - 92

SP - 1902

EP - 1910

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 7

ER -