Physiologic variations in dural venous sinus flow on phase-contrast MR imaging

Neerav R. Mehta, Lisa Jones, Michael A Kraut, Elias R. Melhem

Research output: Contribution to journalArticle

Abstract

OBJECTIVE. Our study quantifies normal physiologic variations of dural sinus flow using phase-contrast MR imaging. SUBJECTS AND METHODS. Fifteen volunteers were imaged using nontriggered and triggered phase-contrast MR venography of the superior sagittal and transverse sinuses. Triggered scans were obtained during regular breathing; nontriggered scans were obtained during regular breathing, breath-holding, deep inspiratory breath-holding, and deep expiratory breath-holding. Analysis of variance, Bonferroni method, and Dunn post hoc analysis were used to determine any significant differences in the mean flow and velocity between the different breathing maneuvers. A paired t test was used to compare flow between sinuses during regular breathing. RESULTS. Deep inspiratory breath-holding and deep expiratory breath-holding resulted in a significant decrease in blood flow and velocity in all dural sinuses compared with regular breathing. During deep inspiratory breath-holding, blood flow decreased 30.8% in the superior sagittal sinus, 19.7% in the left transverse sinus, and 19.1% in the right transverse sinus. Similarly, during deep expiratory breath-holding, blood flow decreased 30.2% in the superior sagittal sinus, 20.8% in the left transverse sinus, and 20.3% in the right transverse sinus. The sum of the flow in the transverse sinuses was significantly greater than in the sagittal sinus. Normal pulsatility of dural sinus blood velocity was also characterized for all measured sinuses. CONCLUSION. Characterization of variations in dural sinus velocity and flow as a function of the cardiac cycle and breathing maneuvers, using phase- contrast MR imaging, may help separate physiologic from pathologic changes of flow resulting from conditions that influence the cerebrovascular circulation.

Original languageEnglish (US)
Pages (from-to)221-225
Number of pages5
JournalAmerican Journal of Roentgenology
Volume175
Issue number1
StatePublished - Jul 2000

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Breath Holding
Transverse Sinuses
Respiration
Superior Sagittal Sinus
Cerebrovascular Circulation
Blood Flow Velocity
Phlebography
Volunteers
Analysis of Variance

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Physiologic variations in dural venous sinus flow on phase-contrast MR imaging. / Mehta, Neerav R.; Jones, Lisa; Kraut, Michael A; Melhem, Elias R.

In: American Journal of Roentgenology, Vol. 175, No. 1, 07.2000, p. 221-225.

Research output: Contribution to journalArticle

Mehta, Neerav R. ; Jones, Lisa ; Kraut, Michael A ; Melhem, Elias R. / Physiologic variations in dural venous sinus flow on phase-contrast MR imaging. In: American Journal of Roentgenology. 2000 ; Vol. 175, No. 1. pp. 221-225.
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abstract = "OBJECTIVE. Our study quantifies normal physiologic variations of dural sinus flow using phase-contrast MR imaging. SUBJECTS AND METHODS. Fifteen volunteers were imaged using nontriggered and triggered phase-contrast MR venography of the superior sagittal and transverse sinuses. Triggered scans were obtained during regular breathing; nontriggered scans were obtained during regular breathing, breath-holding, deep inspiratory breath-holding, and deep expiratory breath-holding. Analysis of variance, Bonferroni method, and Dunn post hoc analysis were used to determine any significant differences in the mean flow and velocity between the different breathing maneuvers. A paired t test was used to compare flow between sinuses during regular breathing. RESULTS. Deep inspiratory breath-holding and deep expiratory breath-holding resulted in a significant decrease in blood flow and velocity in all dural sinuses compared with regular breathing. During deep inspiratory breath-holding, blood flow decreased 30.8{\%} in the superior sagittal sinus, 19.7{\%} in the left transverse sinus, and 19.1{\%} in the right transverse sinus. Similarly, during deep expiratory breath-holding, blood flow decreased 30.2{\%} in the superior sagittal sinus, 20.8{\%} in the left transverse sinus, and 20.3{\%} in the right transverse sinus. The sum of the flow in the transverse sinuses was significantly greater than in the sagittal sinus. Normal pulsatility of dural sinus blood velocity was also characterized for all measured sinuses. CONCLUSION. Characterization of variations in dural sinus velocity and flow as a function of the cardiac cycle and breathing maneuvers, using phase- contrast MR imaging, may help separate physiologic from pathologic changes of flow resulting from conditions that influence the cerebrovascular circulation.",
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