Physiologic and pharmacologic factors that affect myocardial relaxation

Leticia Vittone; Cecilia Mundina-Weilenmann; Alicia Mattiazzi; Horacio Cingolani

doi:10.1016/1056-8719(94)90011-6

Physiologic and pharmacologic factors that affect myocardial relaxation

Leticia Vittone, Cecilia Mundina-Weilenmann, Alicia Mattiazzi, Horacio Cingolani

School of Medicine

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Evaluation of the myocardial relaxation has become important in the last years. An impaired relaxation may precede contractile dysfunctions and even cause heart failure. To treat this impaired lusitropism it is necessary to properly assess the lusitropic state of the heart and understand how drugs affect the cellular mechanisms underlying myocardial relaxation (sarcoplasmic reticulum function, Ca²⁺ fluxes through the sarcolemma and myofilament Ca²⁺ sensitivity). Current information regarding these issues is provided in this review. The relative usefulness of the mechanical parameters used to evaluate the lusitropic state of the heart in experimental models applied in pharmacology will also be discussed.

Original language	English (US)
Pages (from-to)	7-18
Number of pages	12
Journal	Journal of Pharmacological and Toxicological Methods
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/1056-8719(94)90011-6
State	Published - Sep 1994

Keywords

Lusitropism
cellular mechanisms of lusitropic drugs
diastolic function
relaxation parameters

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1016/1056-8719(94)90011-6

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title = "Physiologic and pharmacologic factors that affect myocardial relaxation",

abstract = "Evaluation of the myocardial relaxation has become important in the last years. An impaired relaxation may precede contractile dysfunctions and even cause heart failure. To treat this impaired lusitropism it is necessary to properly assess the lusitropic state of the heart and understand how drugs affect the cellular mechanisms underlying myocardial relaxation (sarcoplasmic reticulum function, Ca2+ fluxes through the sarcolemma and myofilament Ca2+ sensitivity). Current information regarding these issues is provided in this review. The relative usefulness of the mechanical parameters used to evaluate the lusitropic state of the heart in experimental models applied in pharmacology will also be discussed.",

keywords = "Lusitropism, cellular mechanisms of lusitropic drugs, diastolic function, relaxation parameters",

author = "Leticia Vittone and Cecilia Mundina-Weilenmann and Alicia Mattiazzi and Horacio Cingolani",

note = "Funding Information: *Established Investigators of Consejo National de Investigaciones Cientificas y TCcnicas (Argentina). Address reprint requests to Dr. Horatio Cingolani, Centro de Investigaciones Cardiovasculares, Facultad de Ciencias MCdicas, 60 y 120, 1900 LaPlata, Argentina.",

year = "1994",

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doi = "10.1016/1056-8719(94)90011-6",

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T1 - Physiologic and pharmacologic factors that affect myocardial relaxation

AU - Vittone, Leticia

AU - Mundina-Weilenmann, Cecilia

AU - Mattiazzi, Alicia

AU - Cingolani, Horacio

N1 - Funding Information: *Established Investigators of Consejo National de Investigaciones Cientificas y TCcnicas (Argentina). Address reprint requests to Dr. Horatio Cingolani, Centro de Investigaciones Cardiovasculares, Facultad de Ciencias MCdicas, 60 y 120, 1900 LaPlata, Argentina.

PY - 1994/9

Y1 - 1994/9

N2 - Evaluation of the myocardial relaxation has become important in the last years. An impaired relaxation may precede contractile dysfunctions and even cause heart failure. To treat this impaired lusitropism it is necessary to properly assess the lusitropic state of the heart and understand how drugs affect the cellular mechanisms underlying myocardial relaxation (sarcoplasmic reticulum function, Ca2+ fluxes through the sarcolemma and myofilament Ca2+ sensitivity). Current information regarding these issues is provided in this review. The relative usefulness of the mechanical parameters used to evaluate the lusitropic state of the heart in experimental models applied in pharmacology will also be discussed.

AB - Evaluation of the myocardial relaxation has become important in the last years. An impaired relaxation may precede contractile dysfunctions and even cause heart failure. To treat this impaired lusitropism it is necessary to properly assess the lusitropic state of the heart and understand how drugs affect the cellular mechanisms underlying myocardial relaxation (sarcoplasmic reticulum function, Ca2+ fluxes through the sarcolemma and myofilament Ca2+ sensitivity). Current information regarding these issues is provided in this review. The relative usefulness of the mechanical parameters used to evaluate the lusitropic state of the heart in experimental models applied in pharmacology will also be discussed.

KW - Lusitropism

KW - cellular mechanisms of lusitropic drugs

KW - diastolic function

KW - relaxation parameters

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Physiologic and pharmacologic factors that affect myocardial relaxation

Abstract

Keywords

ASJC Scopus subject areas

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