TY - JOUR
T1 - Physiologic activation of T cells via the T cell receptor induces NF-κB
AU - Jamieson, Christina
AU - Mccaffrey, Patricia G.
AU - Rao, Anjana
AU - Sen, Ranjan
PY - 1991/7/15
Y1 - 1991/7/15
N2 - The transcription factor NF-κB has been implicated in the mitogen-induced expression of several genes that are critical for the immunologic function of T cells such as those encoding IL-2 and the IL-2Rα chain (IL-2Rα). We show here that NF-κB is induced in T cells activated by Ag, anti-CD3 antibody, or allogeneic stimulation. The induction of NF-κB via the TCR was dependent on protein kinase C. IL-2, which also activates IL-2Rα expression and proliferation in T cells, was not able to induce NF-κB. TCR-mediated induction of NF-κB suggests a central role for this factor in activated T cells and also provides a mechanism for activation of latent HIV provirus during the normal immune response.
AB - The transcription factor NF-κB has been implicated in the mitogen-induced expression of several genes that are critical for the immunologic function of T cells such as those encoding IL-2 and the IL-2Rα chain (IL-2Rα). We show here that NF-κB is induced in T cells activated by Ag, anti-CD3 antibody, or allogeneic stimulation. The induction of NF-κB via the TCR was dependent on protein kinase C. IL-2, which also activates IL-2Rα expression and proliferation in T cells, was not able to induce NF-κB. TCR-mediated induction of NF-κB suggests a central role for this factor in activated T cells and also provides a mechanism for activation of latent HIV provirus during the normal immune response.
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M3 - Article
C2 - 1830061
AN - SCOPUS:0025915550
SN - 0022-1767
VL - 147
SP - 416
EP - 420
JO - Journal of Immunology
JF - Journal of Immunology
IS - 2
ER -