Physicochemical parameters of individual hexachlorobiphenyl congeners

Terence H Risby, T. B. Hsu, S. S. Sehnert, P. Bhan

Research output: Contribution to journalArticle

Abstract

This study reports the chromatographic quantification of some of the physicochemical parameters for the hexachlorobiphenyls, a group of polychlorinated biphenyls that differ only in the position of chlorine substitution, in order to predict the lipophilicity and subsequent biological activity of these xenobiotics. Various chromatographic methods have been used in this study for the determination of the physiochemical parameters. The partial mole fraction entropies and enthalpies of solution were determined by capillary gas chromatography using two stationary phases. Capacity factors were determined by reverse-phase high-performance liquid chromatography using two bonded packing materials. These data were used to predict 1-octanol/water partition coefficients. On the basis of these studies, gast chromatography is proposed as a superior method to predict lipophilicity since it is not influenced by the steric contributions from the bonded packing materials used in liquid chromatography. Preliminary studies have shown correlation between the partial free energy of solution in an ordered stationary liquid phase and published values for the in vitro induction of microsomal isoenzyme P-450c.

Original languageEnglish (US)
Pages (from-to)1680-1687
Number of pages8
JournalEnvironmental Science and Technology
Volume24
Issue number11
StatePublished - Nov 1990

Fingerprint

liquid chromatography
Isoenzymes
1-Octanol
Polychlorinated Biphenyls
Chlorine
Liquid chromatography
High performance liquid chromatography
Xenobiotics
xenobiotics
Chromatography
Bioactivity
Polychlorinated biphenyls
enthalpy
partition coefficient
Gas chromatography
Free energy
chromatography
entropy
chlorine
Enthalpy

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Science(all)
  • Environmental Chemistry

Cite this

Physicochemical parameters of individual hexachlorobiphenyl congeners. / Risby, Terence H; Hsu, T. B.; Sehnert, S. S.; Bhan, P.

In: Environmental Science and Technology, Vol. 24, No. 11, 11.1990, p. 1680-1687.

Research output: Contribution to journalArticle

Risby, TH, Hsu, TB, Sehnert, SS & Bhan, P 1990, 'Physicochemical parameters of individual hexachlorobiphenyl congeners', Environmental Science and Technology, vol. 24, no. 11, pp. 1680-1687.
Risby, Terence H ; Hsu, T. B. ; Sehnert, S. S. ; Bhan, P. / Physicochemical parameters of individual hexachlorobiphenyl congeners. In: Environmental Science and Technology. 1990 ; Vol. 24, No. 11. pp. 1680-1687.
@article{3087455a443c4098a8babc729518cfc0,
title = "Physicochemical parameters of individual hexachlorobiphenyl congeners",
abstract = "This study reports the chromatographic quantification of some of the physicochemical parameters for the hexachlorobiphenyls, a group of polychlorinated biphenyls that differ only in the position of chlorine substitution, in order to predict the lipophilicity and subsequent biological activity of these xenobiotics. Various chromatographic methods have been used in this study for the determination of the physiochemical parameters. The partial mole fraction entropies and enthalpies of solution were determined by capillary gas chromatography using two stationary phases. Capacity factors were determined by reverse-phase high-performance liquid chromatography using two bonded packing materials. These data were used to predict 1-octanol/water partition coefficients. On the basis of these studies, gast chromatography is proposed as a superior method to predict lipophilicity since it is not influenced by the steric contributions from the bonded packing materials used in liquid chromatography. Preliminary studies have shown correlation between the partial free energy of solution in an ordered stationary liquid phase and published values for the in vitro induction of microsomal isoenzyme P-450c.",
author = "Risby, {Terence H} and Hsu, {T. B.} and Sehnert, {S. S.} and P. Bhan",
year = "1990",
month = "11",
language = "English (US)",
volume = "24",
pages = "1680--1687",
journal = "Environmental Science & Technology",
issn = "0013-936X",
publisher = "American Chemical Society",
number = "11",

}

TY - JOUR

T1 - Physicochemical parameters of individual hexachlorobiphenyl congeners

AU - Risby, Terence H

AU - Hsu, T. B.

AU - Sehnert, S. S.

AU - Bhan, P.

PY - 1990/11

Y1 - 1990/11

N2 - This study reports the chromatographic quantification of some of the physicochemical parameters for the hexachlorobiphenyls, a group of polychlorinated biphenyls that differ only in the position of chlorine substitution, in order to predict the lipophilicity and subsequent biological activity of these xenobiotics. Various chromatographic methods have been used in this study for the determination of the physiochemical parameters. The partial mole fraction entropies and enthalpies of solution were determined by capillary gas chromatography using two stationary phases. Capacity factors were determined by reverse-phase high-performance liquid chromatography using two bonded packing materials. These data were used to predict 1-octanol/water partition coefficients. On the basis of these studies, gast chromatography is proposed as a superior method to predict lipophilicity since it is not influenced by the steric contributions from the bonded packing materials used in liquid chromatography. Preliminary studies have shown correlation between the partial free energy of solution in an ordered stationary liquid phase and published values for the in vitro induction of microsomal isoenzyme P-450c.

AB - This study reports the chromatographic quantification of some of the physicochemical parameters for the hexachlorobiphenyls, a group of polychlorinated biphenyls that differ only in the position of chlorine substitution, in order to predict the lipophilicity and subsequent biological activity of these xenobiotics. Various chromatographic methods have been used in this study for the determination of the physiochemical parameters. The partial mole fraction entropies and enthalpies of solution were determined by capillary gas chromatography using two stationary phases. Capacity factors were determined by reverse-phase high-performance liquid chromatography using two bonded packing materials. These data were used to predict 1-octanol/water partition coefficients. On the basis of these studies, gast chromatography is proposed as a superior method to predict lipophilicity since it is not influenced by the steric contributions from the bonded packing materials used in liquid chromatography. Preliminary studies have shown correlation between the partial free energy of solution in an ordered stationary liquid phase and published values for the in vitro induction of microsomal isoenzyme P-450c.

UR - http://www.scopus.com/inward/record.url?scp=0025514148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025514148&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0025514148

VL - 24

SP - 1680

EP - 1687

JO - Environmental Science & Technology

JF - Environmental Science & Technology

SN - 0013-936X

IS - 11

ER -