Physicians' perspectives regarding pragmatic clinical trials

Rachel Topazian, Juli Bollinger, Kevin P. Weinfurt, Rachel Dvoskin, Debra Mathews, Kathleen Brelsford, Matthew DeCamp, Jeremy Sugarman

Research output: Contribution to journalArticlepeer-review


Aim: Practicing physicians inevitably become involved in pragmatic clinical trials (PCTs), including comparative effectiveness research. We sought to identify physicians' perspectives related to PCTs. Methods: In-depth semistructured interviews with 20 physicians in the USA. Results: Although physicians are generally willing to participate in PCTs, their support is predicated on several factors including expected benefits, minimization of time and workflow burdens and physician engagement. Physicians communicated a desire to respect patients' rights and interests while maintaining a high level of care. Conclusion: Future work is needed to systematically assess the impact of PCTs on clinicians in meeting their ethical obligations to patients and the burdens clinicians are willing to accept in exchange for potential benefits.

Original languageEnglish (US)
Pages (from-to)499-506
Number of pages8
JournalJournal of Comparative Effectiveness Research
Issue number5
StatePublished - Aug 2016


  • comparative effectiveness research
  • ethics
  • qualitative research

ASJC Scopus subject areas

  • Health Policy


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