TY - JOUR
T1 - Physical/chemical/immunologic analytical methods.
AU - Wang, Jia Sheng
AU - Groopman, John D.
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2011
Y1 - 2011
N2 - Biomarkers can be used to measure the presence of a wide variety of parent compounds and metabolites in body fluids and excreta, and serve as biomarkers of internal dose. Chemical-macromolecular adducts formed in blood and tissue or excreted in urine serve as biomarkers of exposure as well, and in many instances reflect both exposure and additional relevant biological processes. An assortment of analytical techniques have been developed to identify and measure parent compounds, metabolites, chemical-DNA and protein adducts. This chapter will discuss many analytical techniques that measure biomarkers in molecular epidemiologic studies, including biological, physical, chemical and immunological methods.
AB - Biomarkers can be used to measure the presence of a wide variety of parent compounds and metabolites in body fluids and excreta, and serve as biomarkers of internal dose. Chemical-macromolecular adducts formed in blood and tissue or excreted in urine serve as biomarkers of exposure as well, and in many instances reflect both exposure and additional relevant biological processes. An assortment of analytical techniques have been developed to identify and measure parent compounds, metabolites, chemical-DNA and protein adducts. This chapter will discuss many analytical techniques that measure biomarkers in molecular epidemiologic studies, including biological, physical, chemical and immunological methods.
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M3 - Review article
C2 - 22997856
AN - SCOPUS:84867299042
SN - 0300-5038
SP - 43
EP - 61
JO - IARC scientific publications
JF - IARC scientific publications
IS - 163
ER -