Physical separation and characterization of two types of benzodiazepine receptors

M. M S Lo, S. M. Strittmatter, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Two distinct benzodiazepine receptors are solubilized differentially by various detergents. The receptor sites that resist solubilization, designated type I, are most highly concentrated in the cerebellum and corpus striatum whereas the more readily solubilized receptors, type II, are most enriched in the hippocampus. The type I receptors display higher affinity for β-carboline esters and a triazolopyridazine whereas several benzodiazepines do not differentiate the two receptors. The type I receptors can be solubilized with 2% Triton X-100/1 M NaCl; they retain the same drug specificity as in the particulate state.

Original languageEnglish (US)
Pages (from-to)680-684
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume79
Issue number2 I
StatePublished - 1982

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Corpus Striatum
Carbolines
Octoxynol
GABA-A Receptors
Benzodiazepines
Detergents
Cerebellum
Hippocampus
Esters
Pharmaceutical Preparations

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Physical separation and characterization of two types of benzodiazepine receptors. / Lo, M. M S; Strittmatter, S. M.; Snyder, Solomon H.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 79, No. 2 I, 1982, p. 680-684.

Research output: Contribution to journalArticle

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