Physical compatibility of magnesium sulfate and sodium bicarbonate in a pharmacy-compounded hemofiltration solution

Brad Moriyama, Stacey A. Henning, Haksong Jin, Michael Kolf, Nadja N. Rehak, Robert L. Danner, Thomas J. Walsh, George J. Grimes

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose. The physical compatibility of magnesium sulfate and sodium bicarbonate in a pharmacy-compounded hemofiltration solution was assessed. Methods. Two bicarbonate-buffered hemofiltration solutions (low- and high-magnesium formulations) were compounded in triplicate. The concentrations of magnesium (15 meq/L) and sodium bicarbonate (50 meq/L) in the high-magnesium formulation were chosen to be somewhat below the concentrations reported as being incompatible in a popular reference. The six hemofiltration bags were stored at 22-25°C without protection from light for 48 hours. Physical compatibility was assessed by visual inspection and microscopy. The pH of the solutions was assayed 3-4 and 52-53 hours after compounding. Electrolyte and glucose concentrations of the solutions were assayed at 3-4 and 50-51 hours after preparation. Results. No particulate matter was observed by visual or microscopic inspection in the compounded hemofiltration solutions at 48 hours. The mean ± S.D. pH values of the low-magnesium solutions were 8.01 ± 0.02 and 8.04 ± 0.02 at 3-4 and 52-53 hours after compounding, respectively. The mean ± S.D. pH values of the high-magnesium solutions were 7.96 ± 0.02 and 7.98 ± 0.01 at 3-4 and 52-53 hours after compounding, respectively. The electrolyte and glucose concentrations in the low- and high-magnesium solutions were similar 3-4 and 50-51 hours after preparation. Conclusion. Magnesium sulfate 1.5 meq/L and sodium bicarbonate 50 meq/L were physically compatible in a pharmacy-compounded hemofiltration solution for 48 hours when stored at 22-25°C without protection from light.

Original languageEnglish (US)
Pages (from-to)562-565
Number of pages4
JournalAmerican Journal of Health-System Pharmacy
Volume67
Issue number7
DOIs
StatePublished - Apr 1 2010

Keywords

  • Compounding
  • Concentration
  • Dextrose
  • Diluents
  • Electrolytes
  • Filtration
  • Hydrogen ion concentration
  • Incompatibilities
  • Magnesium sulfate
  • Sodium bicarbonate
  • Solutions
  • Stability
  • Storage

ASJC Scopus subject areas

  • Pharmacology
  • Health Policy

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