Physical activity predicts microstructural integrity in memory-related networks in very old adults

Qu Tian, Kirk I. Erickson, Eleanor Marie Simonsick, Howard J. Aizenstein, Nancy W. Glynn, Robert M. Boudreau, Anne B. Newman, Stephen B. Kritchevsky, Kristine Yaffe, Tamara B. Harris, Caterina Rosano

Research output: Contribution to journalArticle

Abstract

Background: Although the beneficial effects of physical activity (PA) on memory and executive function are well established in older adults, little is known about the relationship between PA and brain microstructure and the contributions of physical functional limitations and chronic diseases. This study examined whether higher PA would be longitudinally associated with greater microstructural integrity in memory- and executive function-related networks and whether these associations would be independent of physical function and chronic diseases. Methods: Diffusion tensor imaging was obtained in 2006-2008 in 276 participants (mean age = 83.0 years, 58.7% female, 41.3% black) with PA (sedentary, lifestyle active, and exercise active) measured in 1997-1998. Gait speed, cognition, depressive symptoms, cardiovascular and pulmonary diseases, hypertension, stroke, and diabetes were measured at both time points. Mean diffusivity and fractional anisotropy were computed from normal-appearing gray and white matter in frontoparietal and subcortical networks. Moderating effects of physical function and chronic diseases were tested using hierarchical regression models. Results: Compared with the sedentary, the exercise active group had lower mean diffusivity in the medial temporal lobe and the cingulate cortex (β, p values:-405,.023 and-497,.006, respectively), independent of age, sex, and race. Associations remained independent of other variables, although they were attenuated after adjustment for diabetes. Associations between PA and other neuroimaging markers were not significant. Conclusions: Being exercise active predicts greater memory-related microstructural integrity in older adults. Future studies in older adults with diabetes are warranted to examine the neuroprotective effect of PA in these networks.

Original languageEnglish (US)
Pages (from-to)1284-1290
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume69
Issue number10
DOIs
StatePublished - 2014
Externally publishedYes

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Exercise
Chronic Disease
Executive Function
Sedentary Lifestyle
Diffusion Tensor Imaging
Gyrus Cinguli
Anisotropy
Neuroprotective Agents
Temporal Lobe
Pulmonary Hypertension
Neuroimaging
Cognition
Lung Diseases
Cardiovascular Diseases
Stroke
Depression
Brain

Keywords

  • Brain aging
  • Epidemiology
  • Neuroimaging
  • Physical activity

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Physical activity predicts microstructural integrity in memory-related networks in very old adults. / Tian, Qu; Erickson, Kirk I.; Simonsick, Eleanor Marie; Aizenstein, Howard J.; Glynn, Nancy W.; Boudreau, Robert M.; Newman, Anne B.; Kritchevsky, Stephen B.; Yaffe, Kristine; Harris, Tamara B.; Rosano, Caterina.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 69, No. 10, 2014, p. 1284-1290.

Research output: Contribution to journalArticle

Tian, Q, Erickson, KI, Simonsick, EM, Aizenstein, HJ, Glynn, NW, Boudreau, RM, Newman, AB, Kritchevsky, SB, Yaffe, K, Harris, TB & Rosano, C 2014, 'Physical activity predicts microstructural integrity in memory-related networks in very old adults', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 69, no. 10, pp. 1284-1290. https://doi.org/10.1093/gerona/glt287
Tian, Qu ; Erickson, Kirk I. ; Simonsick, Eleanor Marie ; Aizenstein, Howard J. ; Glynn, Nancy W. ; Boudreau, Robert M. ; Newman, Anne B. ; Kritchevsky, Stephen B. ; Yaffe, Kristine ; Harris, Tamara B. ; Rosano, Caterina. / Physical activity predicts microstructural integrity in memory-related networks in very old adults. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2014 ; Vol. 69, No. 10. pp. 1284-1290.
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AU - Tian, Qu

AU - Erickson, Kirk I.

AU - Simonsick, Eleanor Marie

AU - Aizenstein, Howard J.

AU - Glynn, Nancy W.

AU - Boudreau, Robert M.

AU - Newman, Anne B.

AU - Kritchevsky, Stephen B.

AU - Yaffe, Kristine

AU - Harris, Tamara B.

AU - Rosano, Caterina

PY - 2014

Y1 - 2014

N2 - Background: Although the beneficial effects of physical activity (PA) on memory and executive function are well established in older adults, little is known about the relationship between PA and brain microstructure and the contributions of physical functional limitations and chronic diseases. This study examined whether higher PA would be longitudinally associated with greater microstructural integrity in memory- and executive function-related networks and whether these associations would be independent of physical function and chronic diseases. Methods: Diffusion tensor imaging was obtained in 2006-2008 in 276 participants (mean age = 83.0 years, 58.7% female, 41.3% black) with PA (sedentary, lifestyle active, and exercise active) measured in 1997-1998. Gait speed, cognition, depressive symptoms, cardiovascular and pulmonary diseases, hypertension, stroke, and diabetes were measured at both time points. Mean diffusivity and fractional anisotropy were computed from normal-appearing gray and white matter in frontoparietal and subcortical networks. Moderating effects of physical function and chronic diseases were tested using hierarchical regression models. Results: Compared with the sedentary, the exercise active group had lower mean diffusivity in the medial temporal lobe and the cingulate cortex (β, p values:-405,.023 and-497,.006, respectively), independent of age, sex, and race. Associations remained independent of other variables, although they were attenuated after adjustment for diabetes. Associations between PA and other neuroimaging markers were not significant. Conclusions: Being exercise active predicts greater memory-related microstructural integrity in older adults. Future studies in older adults with diabetes are warranted to examine the neuroprotective effect of PA in these networks.

AB - Background: Although the beneficial effects of physical activity (PA) on memory and executive function are well established in older adults, little is known about the relationship between PA and brain microstructure and the contributions of physical functional limitations and chronic diseases. This study examined whether higher PA would be longitudinally associated with greater microstructural integrity in memory- and executive function-related networks and whether these associations would be independent of physical function and chronic diseases. Methods: Diffusion tensor imaging was obtained in 2006-2008 in 276 participants (mean age = 83.0 years, 58.7% female, 41.3% black) with PA (sedentary, lifestyle active, and exercise active) measured in 1997-1998. Gait speed, cognition, depressive symptoms, cardiovascular and pulmonary diseases, hypertension, stroke, and diabetes were measured at both time points. Mean diffusivity and fractional anisotropy were computed from normal-appearing gray and white matter in frontoparietal and subcortical networks. Moderating effects of physical function and chronic diseases were tested using hierarchical regression models. Results: Compared with the sedentary, the exercise active group had lower mean diffusivity in the medial temporal lobe and the cingulate cortex (β, p values:-405,.023 and-497,.006, respectively), independent of age, sex, and race. Associations remained independent of other variables, although they were attenuated after adjustment for diabetes. Associations between PA and other neuroimaging markers were not significant. Conclusions: Being exercise active predicts greater memory-related microstructural integrity in older adults. Future studies in older adults with diabetes are warranted to examine the neuroprotective effect of PA in these networks.

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