PhyloOncology: Understanding cancer through phylogenetic analysis

Jason A. Somarelli, Kathryn E. Ware, Rumen Kostadinov, Jeffrey M. Robinson, Hakima Amri, Mones Abu-Asab, Nicolaas Fourie, Rui Diogo, David Swofford, Jeffrey P. Townsend

Research output: Contribution to journalArticle

Abstract

Despite decades of research and an enormity of resultant data, cancer remains a significant public health problem. New tools and fresh perspectives are needed to obtain fundamental insights, to develop better prognostic and predictive tools, and to identify improved therapeutic interventions. With increasingly common genome-scale data, one suite of algorithms and concepts with potential to shed light on cancer biology is phylogenetics, a scientific discipline used in diverse fields. From grouping subsets of cancer samples to tracing subclonal evolution during cancer progression and metastasis, the use of phylogenetics is a powerful systems biology approach. Well-developed phylogenetic applications provide fast, robust approaches to analyze high-dimensional, heterogeneous cancer data sets. This article is part of a Special Issue entitled: Evolutionary principles - heterogeneity in cancer?, edited by Dr. Robert A. Gatenby.

Original languageEnglish (US)
JournalBiochimica et Biophysica Acta - Reviews on Cancer
DOIs
StateAccepted/In press - Jul 20 2016

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Neoplasms
Systems Biology
Public Health
Genome
Neoplasm Metastasis
Research
Therapeutics
Datasets

Keywords

  • Cancer stratification
  • Cancer types
  • Clonal evolution
  • Tumor heterogeneity
  • Tumor trees

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

Cite this

Somarelli, J. A., Ware, K. E., Kostadinov, R., Robinson, J. M., Amri, H., Abu-Asab, M., ... Townsend, J. P. (Accepted/In press). PhyloOncology: Understanding cancer through phylogenetic analysis. Biochimica et Biophysica Acta - Reviews on Cancer. https://doi.org/10.1016/j.bbcan.2016.10.006

PhyloOncology : Understanding cancer through phylogenetic analysis. / Somarelli, Jason A.; Ware, Kathryn E.; Kostadinov, Rumen; Robinson, Jeffrey M.; Amri, Hakima; Abu-Asab, Mones; Fourie, Nicolaas; Diogo, Rui; Swofford, David; Townsend, Jeffrey P.

In: Biochimica et Biophysica Acta - Reviews on Cancer, 20.07.2016.

Research output: Contribution to journalArticle

Somarelli, JA, Ware, KE, Kostadinov, R, Robinson, JM, Amri, H, Abu-Asab, M, Fourie, N, Diogo, R, Swofford, D & Townsend, JP 2016, 'PhyloOncology: Understanding cancer through phylogenetic analysis', Biochimica et Biophysica Acta - Reviews on Cancer. https://doi.org/10.1016/j.bbcan.2016.10.006
Somarelli, Jason A. ; Ware, Kathryn E. ; Kostadinov, Rumen ; Robinson, Jeffrey M. ; Amri, Hakima ; Abu-Asab, Mones ; Fourie, Nicolaas ; Diogo, Rui ; Swofford, David ; Townsend, Jeffrey P. / PhyloOncology : Understanding cancer through phylogenetic analysis. In: Biochimica et Biophysica Acta - Reviews on Cancer. 2016.
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