Phylogeny of Vibrio cholerae based on recA sequence

O. Colin Stine, Shanmuga Sozhamannan, Qing Gou, Siqen Zheng, J. Glenn Morris, Judith A. Johnson

Research output: Contribution to journalArticlepeer-review


We sequenced a 705-bp fragment of the recA gene from 113 Vibrio cholerae strains and closely related species. One hundred eighty-seven nucleotides were phylogenetically informative, 55 were phylogenetically uninformative, and 463 were invariant. Not unexpectedly, Vibrio parahaemolyticus and Vibrio vulnificus strains formed out-groups; we also identified isolates which resembled V. cholerae biochemically but which did not cluster with V. cholerae. In many instances, V. cholerae serogroup designations did not correlate with phylogeny, as reflected by recA sequence divergence. This observation is consistent with the idea that there is horizontal transfer of O-antigen biosynthesis genes among V. cholerae strains.

Original languageEnglish (US)
Pages (from-to)7180-7185
Number of pages6
JournalInfection and Immunity
Issue number12
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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