Phylogeny of functional humoral transplantation immunity: comparative studies in amphibians and rodents.

N. Cohen, W. M. Baldwin, V. Manickavel

Research output: Contribution to journalArticlepeer-review

Abstract

Remarkably comparable observations from parallel experiments in salamanders and mice utilizing three related model systems (implant-induced immunomanipulation; passive transfer; and putative B cell suppression) argue directly that functional humoral transplantation immunity is highly developed at the phylogenetic level of Amphibia and that it plays a major role in regulating graft survival in these species (Fig. 4). Although it is still conjectural whether such humoral immunity and weak H-antigens evolved concurrently, the argument that enhancing atibodies evolved exclusively in viviparous species to protect the fetus from potential rejection by the maternal immune system no longer seems tenable (1).

Original languageEnglish (US)
Pages (from-to)411-420
Number of pages10
JournalAdvances in Experimental Medicine and Biology
Volume64
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Phylogeny of functional humoral transplantation immunity: comparative studies in amphibians and rodents.'. Together they form a unique fingerprint.

Cite this