Phylogenetic distribution of a 24,000 dalton human leukemia-associated antigen on platelets and kidney cells

Barry L. Dowell, Francis L. Tuck, Michael J. Borowitz, Tucker W. LeBien, Richard S. Metzgar

Research output: Contribution to journalArticlepeer-review

Abstract

The distribution of a 24,000-dalton human leukemia-associated antigen, p24, was examined using the BA-2 and DU-ALL-1 monoclonal antibodies. BA-2 and DU-ALL-1 bound to human, gorilla, orangutan, macaque, and rabbit platelets but did not bind to mouse, rat, guinea pig, dog, horse, sheep, or goat platelets. Orangutan platelets demonstrated a decreased level of binding with BA-2 and DU-ALL-1. In addition, BA-2, but not DU-ALL-1, bound to chimpanzee platelets suggesting that the chimpanzee has lost the epitope of p24 detected by DU-ALL-1. Immunoperoxidase analysis of kidney tissue with BA-2 and DU-ALL-1 revealed staining of distal tubules and glomeruli, which occurred in a similar phylogenetic distribution to that of p24 on platelets. A monoclonal antibody to the high molecular weight common ALL antigen, J-5, reacted with glomeruli and proximal tubules from human, chimpanzee, orangutan, mangaby, rhesus, and rabbit kidneys but failed to react with rat or mouse kidney.

Original languageEnglish (US)
Pages (from-to)187-195
Number of pages9
JournalDevelopmental and Comparative Immunology
Volume8
Issue number1
DOIs
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Phylogenetic distribution of a 24,000 dalton human leukemia-associated antigen on platelets and kidney cells'. Together they form a unique fingerprint.

Cite this