TY - JOUR
T1 - PHR1, a PH domain-containing protein expressed in primary sensory neurons
AU - Xu, Shunbin
AU - Wang, Yanshu
AU - Zhao, Haiqing
AU - Zhang, Lilei
AU - Xiong, Weihong
AU - Yau, King Wai
AU - Hiel, Hakim
AU - Glowatzki, Elisabeth
AU - Ryugo, David K.
AU - Valle, David
PY - 2004/10
Y1 - 2004/10
N2 - Previously, we identified PHR1 as an abundantly expressed gene in photoreceptors and showed that it encodes four isoforms, each with N-terminal pleckstrin homology (PH) and C-terminal transmembrane domains. To better understand PHR1 function and expression, we made a Phr1 null mouse by inserting a β-galactosidase/neor cassette into exon 3. In addition to photoreceptors, we found abundant expression of specific Phr1 splice forms in olfactory receptor neurons and vestibular and cochlear hair cells. We also found Phr1 expression in cells with a possible sensory function, including peripheral retinal ganglion cells, cochlear interdental cells, and neurons of the circumventricular organ. Despite this discrete expression in known and putative sensory neurons, mice lacking PHR1 do not have overt sensory deficits.
AB - Previously, we identified PHR1 as an abundantly expressed gene in photoreceptors and showed that it encodes four isoforms, each with N-terminal pleckstrin homology (PH) and C-terminal transmembrane domains. To better understand PHR1 function and expression, we made a Phr1 null mouse by inserting a β-galactosidase/neor cassette into exon 3. In addition to photoreceptors, we found abundant expression of specific Phr1 splice forms in olfactory receptor neurons and vestibular and cochlear hair cells. We also found Phr1 expression in cells with a possible sensory function, including peripheral retinal ganglion cells, cochlear interdental cells, and neurons of the circumventricular organ. Despite this discrete expression in known and putative sensory neurons, mice lacking PHR1 do not have overt sensory deficits.
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U2 - 10.1128/MCB.24.20.9137-9151.2004
DO - 10.1128/MCB.24.20.9137-9151.2004
M3 - Article
C2 - 15456885
AN - SCOPUS:4744369218
SN - 0270-7306
VL - 24
SP - 9137
EP - 9151
JO - Molecular and cellular biology
JF - Molecular and cellular biology
IS - 20
ER -