Phototransduction in Rods and Cones

D. G. Luo, V. Kefalov, K. W. Yau

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Phototransduction is the first step in seeing, whereby photons absorbed by the retinal rods and cones trigger an electrical signal, which is then transmitted synaptically to higher-order retinal neurons for processing. The mechanism of phototransduction is now extremely well understood, especially that of rods, and is in fact the exemplary G-protein-mediated signaling pathway understood down to quantitative details. The molecular identifications of the various proteins involved in phototransduction and their mutations have also helped understand many hereditary diseases affecting vision.

Original languageEnglish (US)
Title of host publicationVision I
PublisherElsevier Inc.
Pages269-301
Number of pages33
Volume1
ISBN (Print)9780123708809
DOIs
StatePublished - Jan 1 2008

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Keywords

  • Bleaching adaptation
  • CGMP
  • Ciliary photoreceptor
  • Cone
  • Cone pigment
  • Dark adaptation
  • Evolution
  • Light adaptation
  • Light response
  • Parietal eye
  • Photoreceptor
  • Phototransduction
  • Retina
  • Rhodopsin
  • Rod
  • Visual pigment

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Luo, D. G., Kefalov, V., & Yau, K. W. (2008). Phototransduction in Rods and Cones. In Vision I (Vol. 1, pp. 269-301). Elsevier Inc.. https://doi.org/10.1016/B978-012370880-9.00258-9