Photothermal bundle measurement of phantoms and blood as a proof of concept for oxygenation saturation measurement

Yonat Milstein, Michal Tepper, Moshe Ben David, James A. Harrington, Israel Gannot

Research output: Contribution to journalLetter

Abstract

This study objective is to validate a method for the measurement of two compound phantoms as a proof of concept for oxygen saturation level measurement via a thermal imaging bundle. The method consists of a thermal imaging system and an algorithm which estimates the compound concentration according to temperature rise. A temperature rise is obtained by illuminating the tissue with a laser with different wavelengths in the NIR range and measured using a thermal camera. A coherent thermal imaging bundle was used for image transmittance for minimal invasive transendoscopic use. The algorithm's estimation ability was evaluated using agar phantoms of varying Methylene Blue and ICG ratios as well as blood samples The Methylene Blue ratio in each phantom was estimated and the calculated average RMS of the error was 9.38%, a satisfying value for this stage, verifying the algorithm's and bundle's suitability for the use in a minimal invasive system.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalJournal of biophotonics
Volume4
Issue number4
DOIs
StatePublished - Apr 1 2011
Externally publishedYes

Keywords

  • Coherent fiber bundle
  • Coherent optical systems
  • Infrared imaging
  • Photothermal spectroscopy
  • Thermal imaging
  • Tissue oxygenation

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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