TY - JOUR
T1 - Phototherapy for scleroderma
T2 - Biologic rationale, results, and promise
AU - Fisher, Gary J.
AU - Kang, Sewon
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2002/11
Y1 - 2002/11
N2 - Scleroderma is a chronic disease of connective tissue characterized by deposition of large amounts of collagen. Localized scleroderma affects only the skin, whereas systemic disease, systemic sclerosis, may affect the lungs, gastrointestinal tract, kidneys, and heart in addition to the skin. Although the various forms of localized scleroderma are not life threatening, they result in considerable morbidity owing to joint contracture, loss of flexibility, and disfigurement. Although many different treatments have been attempted, until now none has proven to be effective. Accumulating evidence indicates that UVA irradiation offers a genuine opportunity to ameliorate localized scleroderma and the cutaneous manifestations of systemic sclerosis.
AB - Scleroderma is a chronic disease of connective tissue characterized by deposition of large amounts of collagen. Localized scleroderma affects only the skin, whereas systemic disease, systemic sclerosis, may affect the lungs, gastrointestinal tract, kidneys, and heart in addition to the skin. Although the various forms of localized scleroderma are not life threatening, they result in considerable morbidity owing to joint contracture, loss of flexibility, and disfigurement. Although many different treatments have been attempted, until now none has proven to be effective. Accumulating evidence indicates that UVA irradiation offers a genuine opportunity to ameliorate localized scleroderma and the cutaneous manifestations of systemic sclerosis.
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U2 - 10.1097/00002281-200211000-00016
DO - 10.1097/00002281-200211000-00016
M3 - Review article
C2 - 12410098
AN - SCOPUS:0036838771
SN - 1040-8711
VL - 14
SP - 723
EP - 726
JO - Current opinion in rheumatology
JF - Current opinion in rheumatology
IS - 6
ER -