Abstract
PURPOSE. To better understand how photoreceptors and their circuits support luminancedependent spatial visual behavior. METHODS. Grating thresholds for optokinetic tracking were measured under defined luminance conditions in mice with genetic alterations of photoreceptor activity. RESULTS. The luminance conditions that enable cone- and rod-mediated behavior, and the luminance range over which rod and cone functions overlap, were characterized. The AII amacrine pathway was found to support low-resolution and high-contrast function, with the rod–cone pathway supporting high-resolution and low-contrast function. Rods alone were also shown to be capable of driving cone-like spatial visual function, but only when cones were genetically maintained in a physiological dark state. CONCLUSIONS. The study defined how luminance signals drive rod- and cone-mediated spatial visual behavior and revealed new and unexpected contributions for rods that depend on an interaction between cone and rod systems.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1842-1849 |
| Number of pages | 8 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 56 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 10 2015 |
Fingerprint
Keywords
- Cone
- ipRGC
- Melanopsin
- Mesopic
- Optokinetic tracking
- Photopic
- Photoreceptors
- Rod
- Scotopic
- Spatial vision
- Visual behavior
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
- Medicine(all)
Cite this
Photoreceptor regulation of spatial visual behavior. / Alam, Nazia M.; Altimus, Cara M.; Douglas, Robert M.; Hattar, Samer; Prusky, Glen T.
In: Investigative Ophthalmology and Visual Science, Vol. 56, No. 3, 10.02.2015, p. 1842-1849.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Photoreceptor regulation of spatial visual behavior
AU - Alam, Nazia M.
AU - Altimus, Cara M.
AU - Douglas, Robert M.
AU - Hattar, Samer
AU - Prusky, Glen T.
PY - 2015/2/10
Y1 - 2015/2/10
N2 - PURPOSE. To better understand how photoreceptors and their circuits support luminancedependent spatial visual behavior. METHODS. Grating thresholds for optokinetic tracking were measured under defined luminance conditions in mice with genetic alterations of photoreceptor activity. RESULTS. The luminance conditions that enable cone- and rod-mediated behavior, and the luminance range over which rod and cone functions overlap, were characterized. The AII amacrine pathway was found to support low-resolution and high-contrast function, with the rod–cone pathway supporting high-resolution and low-contrast function. Rods alone were also shown to be capable of driving cone-like spatial visual function, but only when cones were genetically maintained in a physiological dark state. CONCLUSIONS. The study defined how luminance signals drive rod- and cone-mediated spatial visual behavior and revealed new and unexpected contributions for rods that depend on an interaction between cone and rod systems.
AB - PURPOSE. To better understand how photoreceptors and their circuits support luminancedependent spatial visual behavior. METHODS. Grating thresholds for optokinetic tracking were measured under defined luminance conditions in mice with genetic alterations of photoreceptor activity. RESULTS. The luminance conditions that enable cone- and rod-mediated behavior, and the luminance range over which rod and cone functions overlap, were characterized. The AII amacrine pathway was found to support low-resolution and high-contrast function, with the rod–cone pathway supporting high-resolution and low-contrast function. Rods alone were also shown to be capable of driving cone-like spatial visual function, but only when cones were genetically maintained in a physiological dark state. CONCLUSIONS. The study defined how luminance signals drive rod- and cone-mediated spatial visual behavior and revealed new and unexpected contributions for rods that depend on an interaction between cone and rod systems.
KW - Cone
KW - ipRGC
KW - Melanopsin
KW - Mesopic
KW - Optokinetic tracking
KW - Photopic
KW - Photoreceptors
KW - Rod
KW - Scotopic
KW - Spatial vision
KW - Visual behavior
UR - http://www.scopus.com/inward/record.url?scp=84925340787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925340787&partnerID=8YFLogxK
U2 - 10.1167/iovs.14-15644
DO - 10.1167/iovs.14-15644
M3 - Article
C2 - 25670495
AN - SCOPUS:84925340787
VL - 56
SP - 1842
EP - 1849
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 3
ER -