Photoreceptor regulation of spatial visual behavior

Nazia M. Alam, Cara M. Altimus, Robert M. Douglas, Samer Hattar, Glen T. Prusky

Research output: Contribution to journalArticle

Abstract

PURPOSE. To better understand how photoreceptors and their circuits support luminancedependent spatial visual behavior. METHODS. Grating thresholds for optokinetic tracking were measured under defined luminance conditions in mice with genetic alterations of photoreceptor activity. RESULTS. The luminance conditions that enable cone- and rod-mediated behavior, and the luminance range over which rod and cone functions overlap, were characterized. The AII amacrine pathway was found to support low-resolution and high-contrast function, with the rod–cone pathway supporting high-resolution and low-contrast function. Rods alone were also shown to be capable of driving cone-like spatial visual function, but only when cones were genetically maintained in a physiological dark state. CONCLUSIONS. The study defined how luminance signals drive rod- and cone-mediated spatial visual behavior and revealed new and unexpected contributions for rods that depend on an interaction between cone and rod systems.

Original languageEnglish (US)
Pages (from-to)1842-1849
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume56
Issue number3
DOIs
StatePublished - Feb 10 2015

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Spatial Behavior
Vertebrate Photoreceptor Cells
Rod-Cone Interaction

Keywords

  • Cone
  • ipRGC
  • Melanopsin
  • Mesopic
  • Optokinetic tracking
  • Photopic
  • Photoreceptors
  • Rod
  • Scotopic
  • Spatial vision
  • Visual behavior

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Alam, N. M., Altimus, C. M., Douglas, R. M., Hattar, S., & Prusky, G. T. (2015). Photoreceptor regulation of spatial visual behavior. Investigative Ophthalmology and Visual Science, 56(3), 1842-1849. https://doi.org/10.1167/iovs.14-15644

Photoreceptor regulation of spatial visual behavior. / Alam, Nazia M.; Altimus, Cara M.; Douglas, Robert M.; Hattar, Samer; Prusky, Glen T.

In: Investigative Ophthalmology and Visual Science, Vol. 56, No. 3, 10.02.2015, p. 1842-1849.

Research output: Contribution to journalArticle

Alam, NM, Altimus, CM, Douglas, RM, Hattar, S & Prusky, GT 2015, 'Photoreceptor regulation of spatial visual behavior', Investigative Ophthalmology and Visual Science, vol. 56, no. 3, pp. 1842-1849. https://doi.org/10.1167/iovs.14-15644
Alam, Nazia M. ; Altimus, Cara M. ; Douglas, Robert M. ; Hattar, Samer ; Prusky, Glen T. / Photoreceptor regulation of spatial visual behavior. In: Investigative Ophthalmology and Visual Science. 2015 ; Vol. 56, No. 3. pp. 1842-1849.
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