Abstract
This study was undertaken to quantify retinal and intra-retinal layer thicknesses in Parkinson's disease (PD), and to evaluate whether retinal structural changes may be related to altered discrimination of color vision and to severity and duration of PD disease. We examined 97 PD patients and 32 healthy controls (HC) with spectral-domain optical coherence tomography (OCT), including intra-retinal layer segmentation. In total, we compared 111 retinal nerve fiber layer (RNFL)-scans and 114 macula scans from 68 PD patients with 62 RNFL and 63 macula scans from 32 HC. For clinical evaluation of disease severity, we used the Unified Parkinson's Disease Rating Scale (UPDRS) motor examination. To determine color discrimination, we performed the Farnsworth Munsell 100 Hue Test (FMT) in a subgroup of PD patients. We found significant combined outer nuclear and photoreceptor layer thinning in PD versus HC (118.6 vs. 123.5 μm, P=0.001). Differences in RNFL, total macular volume, or the other retinal layer thicknesses were not detected. The OCT measures were not associated with disease severity, duration, or color vision. By showing photoreceptor cell layer thinning, our findings support previous in vivo and autopsy studies demonstrating retinal alterations in PD. Optical coherence tomography may help to assess morphological retinal changes in PD patients; however, the utility of OCT in routine clinical practice may be limited because many PD patients have difficulties complying with OCT investigation because of disease-related symptoms such as tremor, axial rigidity, or cognitive impairment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1163-1170 |
| Number of pages | 8 |
| Journal | Movement disorders : official journal of the Movement Disorder Society |
| Volume | 29 |
| Issue number | 9 |
| DOIs | |
| State | Published - 2014 |
Fingerprint
Keywords
- Optical coherence tomography
- Parkinson's disease
- Retina, photoreceptor layer
- Visual dysfunction
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Medicine(all)
Cite this
Photoreceptor layer thinning in idiopathic Parkinson's disease. / Roth, Nicolas M.; Saidha, Shiv; Zimmermann, Hanna; Brandt, Alexander U.; Isensee, Justine; Benkhellouf-Rutkowska, Agnieszka; Dornauer, Matthias; Kühn, Andrea A.; Müller, Thomas; Calabresi, Peter; Paul, Friedemann.
In: Movement disorders : official journal of the Movement Disorder Society, Vol. 29, No. 9, 2014, p. 1163-1170.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Photoreceptor layer thinning in idiopathic Parkinson's disease
AU - Roth, Nicolas M.
AU - Saidha, Shiv
AU - Zimmermann, Hanna
AU - Brandt, Alexander U.
AU - Isensee, Justine
AU - Benkhellouf-Rutkowska, Agnieszka
AU - Dornauer, Matthias
AU - Kühn, Andrea A.
AU - Müller, Thomas
AU - Calabresi, Peter
AU - Paul, Friedemann
PY - 2014
Y1 - 2014
N2 - This study was undertaken to quantify retinal and intra-retinal layer thicknesses in Parkinson's disease (PD), and to evaluate whether retinal structural changes may be related to altered discrimination of color vision and to severity and duration of PD disease. We examined 97 PD patients and 32 healthy controls (HC) with spectral-domain optical coherence tomography (OCT), including intra-retinal layer segmentation. In total, we compared 111 retinal nerve fiber layer (RNFL)-scans and 114 macula scans from 68 PD patients with 62 RNFL and 63 macula scans from 32 HC. For clinical evaluation of disease severity, we used the Unified Parkinson's Disease Rating Scale (UPDRS) motor examination. To determine color discrimination, we performed the Farnsworth Munsell 100 Hue Test (FMT) in a subgroup of PD patients. We found significant combined outer nuclear and photoreceptor layer thinning in PD versus HC (118.6 vs. 123.5 μm, P=0.001). Differences in RNFL, total macular volume, or the other retinal layer thicknesses were not detected. The OCT measures were not associated with disease severity, duration, or color vision. By showing photoreceptor cell layer thinning, our findings support previous in vivo and autopsy studies demonstrating retinal alterations in PD. Optical coherence tomography may help to assess morphological retinal changes in PD patients; however, the utility of OCT in routine clinical practice may be limited because many PD patients have difficulties complying with OCT investigation because of disease-related symptoms such as tremor, axial rigidity, or cognitive impairment.
AB - This study was undertaken to quantify retinal and intra-retinal layer thicknesses in Parkinson's disease (PD), and to evaluate whether retinal structural changes may be related to altered discrimination of color vision and to severity and duration of PD disease. We examined 97 PD patients and 32 healthy controls (HC) with spectral-domain optical coherence tomography (OCT), including intra-retinal layer segmentation. In total, we compared 111 retinal nerve fiber layer (RNFL)-scans and 114 macula scans from 68 PD patients with 62 RNFL and 63 macula scans from 32 HC. For clinical evaluation of disease severity, we used the Unified Parkinson's Disease Rating Scale (UPDRS) motor examination. To determine color discrimination, we performed the Farnsworth Munsell 100 Hue Test (FMT) in a subgroup of PD patients. We found significant combined outer nuclear and photoreceptor layer thinning in PD versus HC (118.6 vs. 123.5 μm, P=0.001). Differences in RNFL, total macular volume, or the other retinal layer thicknesses were not detected. The OCT measures were not associated with disease severity, duration, or color vision. By showing photoreceptor cell layer thinning, our findings support previous in vivo and autopsy studies demonstrating retinal alterations in PD. Optical coherence tomography may help to assess morphological retinal changes in PD patients; however, the utility of OCT in routine clinical practice may be limited because many PD patients have difficulties complying with OCT investigation because of disease-related symptoms such as tremor, axial rigidity, or cognitive impairment.
KW - Optical coherence tomography
KW - Parkinson's disease
KW - Retina, photoreceptor layer
KW - Visual dysfunction
UR - http://www.scopus.com/inward/record.url?scp=84906046832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906046832&partnerID=8YFLogxK
U2 - 10.1002/mds.25896
DO - 10.1002/mds.25896
M3 - Article
C2 - 24789530
AN - SCOPUS:84906046832
VL - 29
SP - 1163
EP - 1170
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 9
ER -