Photoreceptor differentiation in retinoblastoma

Research output: Contribution to journalArticlepeer-review


Pathologic study of retinoblastoma with photoreceptor differentiation shed light on the histogenesis of this tumor. The light and electron microscopic features of these tumor cells suggested that retinoblastomas are derived from embryonal retinal cells. Morphologic characteristics of Flexner-Wintersteiner rosettes, fleurettes, ependyma and retina were further examined. This comparative study showed that rosettes and fleurettes of retinoblastoma are an attempt to differentiate photoreceptor cells. Fleurettes are a higher form of photoreceptor differentiation than rosettes. Clinically, retinoblastomas with photoreceptor differentiation have distinctive ophthalmoscopic features. Behaviorally, these tumors appear to be less malignant than undifferentiated retinoblastomas but more resistant to radiotherapy.

Original languageEnglish (US)
Pages (from-to)351-357
Number of pages7
JournalJapanese Journal of Ophthalmology
Issue number3
StatePublished - Jan 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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