Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser

K. T. Tsen, Shaw Wei D. Tsen, Q. Fu, S. M. Lindsay, K. Kibler, B. Jacobs, T. C. Wu, Zhe Li, Hao Yan, Stephanie Cope, Sara Vaiana, Juliann G. Kiang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report a photonic approach for selective inactivation of viruses with a near-infrared ultrashort pulsed (USP) laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as M13 bacteriophage, tobacco mosaic virus (TMV) to pathogenic viruses like human papillomavirus (HPV) and human immunodeficiency virus (HIV). At the same time sensitive materials like human Jurkat T cells, human red blood cells, and mouse dendritic cells remain unharmed. Our photonic approach could be used for the disinfection of viral pathogens in blood products and for the treatment of blood-borne viral diseases in the clinic.

Original languageEnglish (US)
Title of host publicationOptical Biopsy VII
DOIs
StatePublished - 2010
EventOptical Biopsy VII - San Francisco, CA, United States
Duration: Jan 25 2010Jan 28 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7561
ISSN (Print)1605-7422

Other

OtherOptical Biopsy VII
CountryUnited States
CitySan Francisco, CA
Period1/25/101/28/10

Keywords

  • Femtosecond lasers
  • Inactivation of viruses
  • Photonics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Tsen, K. T., Tsen, S. W. D., Fu, Q., Lindsay, S. M., Kibler, K., Jacobs, B., Wu, T. C., Li, Z., Yan, H., Cope, S., Vaiana, S., & Kiang, J. G. (2010). Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser. In Optical Biopsy VII [75610W] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7561). https://doi.org/10.1117/12.841316