Terapia fotodinámica con verteporfina en neovascularización coroidea después de cirugía refractiva

Translated title of the contribution: Photodynamic therapy with verteporfin in choroidal neovascularization after refractive surgery

Pedro Amat-Peral, F. Lugo, J. A. Montero, C. De-La-Vega, J. F. Arévalo, Alió Y. Sanz Jl

Research output: Contribution to journalArticle

Abstract

Purpose: To analyze the results obtained with Photodynamic Therapy (PDT) to treat subfoveal and juxtafoveal Choroidal Neovascularization (CNV) in patients with high myopia corrected by Laser-Assisted in situ Keratomileusis (LASIK) or by implanting a Phakic Intraocular Lens (PIOL). Methods: We analyzed the results from 14 highly myopic eyes corrected by LASIK (seven cases) or by PIOL implantation (seven cases), which later developed CNV and were treated by PDT with verteporfin. Results: Mean Best Corrected Visual Acuity (BCVA) after refractive surgery was 0.45 SD 0.17 (range, 0.2 to 0.8), with residual spherical equivalent (RSE) -0.5 SD 1.8 D (range, 1 to 5.5 D). After CNV appearance, BCVA was 0.10 SD 0.19 (range, 0.025 to 0.7). CNV was treated in all cases by PDT (mean, 2.0 SD 0.8 treatments). After CNV closure, the mean BCVA improved up to 0.22 SD 0.18 (range, 0.1 to 0.63) (RSE -1.4 SD 1.4 D, range, 0.5 to -4 D). Differences in RSE after refractive surgery and after PDT, and differences between BCVA after CNV appearance and final were not statistically significant (p=0.82 and p=0.06, respectively, Student's t test paired data). Conclusion: We consider that PDT is effective in achieving closure of CNV in myopic patients after refractive surgery without inducing changes in spherical equivalent.

Original languageSpanish
Pages (from-to)539-544
Number of pages6
JournalArchivos de la Sociedad Espanola de Oftalmologia
Volume83
Issue number9
StatePublished - Sep 1 2008

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Keywords

  • Choroidal neovascularization
  • LASIK
  • Pathologic myopia
  • Phakic intraocular lens implantation
  • Photodynamic therapy
  • Refractive surgery
  • Residual spherical equivalent

ASJC Scopus subject areas

  • Ophthalmology

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