Photodynamic Therapy for Endobronchial Obstruction is Safely Performed with Flexible Bronchoscopy

Armin Ernst, Lutz Freitag, David Feller-Kopman, Joseph LoCicero, David Ost

Research output: Contribution to journalArticle

Abstract

Objective: To determine the safety and efficacy of photodynamic therapy (PDT) in patients with endobronchial tumors using the flexible bronchoscope for light application and debridement bronchoscopy without general anesthesia or the rigid bronchoscope. Method: Thirty-seven consecutive cases with inoperable cancer, either primary or metastatic to the lung, were treated with PDT. PDT was performed using Photofrin® infusion at 2 mg/kg followed by illumination after 48-72 hours. 630 nm laser light was delivered with a cylindrical light diffusing fiber passed through a flexible bronchoscope. Pulmonary hygiene flexible bronchoscopy was performed 48 hours later and as needed to remove necrotic debris. Repeat illumination was done as needed to a maximum of three treatments. Results: There were 32 complete or partial responders and five treatment failures. There was no treatment-related mortality. Major post-operative complications included respiratory failure requiring shortterm intubation in one patient. All illumination and debridement bronchoscopies were performed with the flexible bronchoscope and conscious sedation only Conclusions: PDT is effective for palliation of inoperable advanced lung cancer. PDT and hygiene bronchoscopy can be performed safely and effectively with the flexible bronchoscope alone. General anesthesia and rigid bronchoscopy are not mandatory for effective PDT.

Original languageEnglish (US)
Pages (from-to)260-263
Number of pages4
JournalJournal of Bronchology
Volume10
Issue number4
DOIs
StatePublished - Oct 2003
Externally publishedYes

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Photochemotherapy
Bronchoscopes
Bronchoscopy
Lighting
Debridement
Hygiene
Light
General Anesthesia
Dihematoporphyrin Ether
Conscious Sedation
Lung
Treatment Failure
Intubation
Respiratory Insufficiency
Lung Neoplasms
Neoplasms
Lasers
Safety
Mortality
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Photodynamic Therapy for Endobronchial Obstruction is Safely Performed with Flexible Bronchoscopy. / Ernst, Armin; Freitag, Lutz; Feller-Kopman, David; LoCicero, Joseph; Ost, David.

In: Journal of Bronchology, Vol. 10, No. 4, 10.2003, p. 260-263.

Research output: Contribution to journalArticle

Ernst, Armin ; Freitag, Lutz ; Feller-Kopman, David ; LoCicero, Joseph ; Ost, David. / Photodynamic Therapy for Endobronchial Obstruction is Safely Performed with Flexible Bronchoscopy. In: Journal of Bronchology. 2003 ; Vol. 10, No. 4. pp. 260-263.
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