Photoacoustic imaging of prostate brachytherapy seeds with transurethral light delivery

Muyinatu A. Lediju Bell, Xiaoyu Guo, Danny Y Song, Emad Boctor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a novel approach to photoacoustic imaging of prostate brachytherapy seeds utilizing an existing urinary catheter for transurethral light delivery. Two canine prostates were surgically implanted with brachyther- apy seeds under transrectal ultrasound guidance. One prostate was excised shortly after euthanasia and fixed in gelatin. The second prostate was imaged in the native tissue environment shortly after euthanasia. A urinary catheter was inserted in the urethra of each prostate. A 1-mm core diameter optical fiber coupled to a 1064 nm Nd:YAG laser was inserted into the urinary catheter. Light from the fiber was either directed mostly parallel to the fiber axis (i.e. end-fire fire) or mostly 90°to the fiber axis (i.e. side-fire fiber). An Ultrasonix SonixTouch scanner, transrectal ultrasound probe with curvilinear (BPC8-4) and linear (BPL9-5) arrays, and DAQ unit were utilized for synchronized laser light emission and photoacoustic signal acquisition. The implanted brachytherapy seeds were visualized at radial distances of 6-16 mm from the catheter. Multiple brachytherapy seeds were si- multaneously visualized with each array of the transrectal probe using both delay-and-sum (DAS) and short-lag spatial coherence (SLSC) beamforming. This work is the first to demonstrate the feasibility of photoacoustic imaging of prostate brachytherapy seeds using a transurethral light delivery method.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8943
ISBN (Print)9780819498564
DOIs
StatePublished - 2014
EventPhotons Plus Ultrasound: Imaging and Sensing 2014 - San Francisco, CA, United States
Duration: Feb 2 2014Feb 5 2014

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2014
CountryUnited States
CitySan Francisco, CA
Period2/2/142/5/14

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Keywords

  • Beamforming
  • Optoacoustic imaging
  • Prostate cancer
  • Side-fire probe
  • Side-looking probe

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Lediju Bell, M. A., Guo, X., Song, D. Y., & Boctor, E. (2014). Photoacoustic imaging of prostate brachytherapy seeds with transurethral light delivery. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8943). [89430N] SPIE. https://doi.org/10.1117/12.2040751