TY - JOUR
T1 - Photoacoustic and Magnetic Resonance Imaging Bimodal Contrast Agent Displaying Amplified Photoacoustic Signal
AU - Duan, Yukun
AU - Xu, Yu
AU - Mao, Duo
AU - Liew, Weng Heng
AU - Guo, Bing
AU - Wang, Shaowei
AU - Cai, Xiaolei
AU - Thakor, Nitish
AU - Yao, Kui
AU - Zhang, Chong Jing
AU - Liu, Bin
N1 - Funding Information:
The authors are grateful for financial support from the Singapore NRF Competitive Research Program (R279-000-483-281), National University of Singapore (R279-000-482-133) and NRF Investigatorship (R279-000-444-281). The work at IMRE is partially supported by Singapore NRF through grant NRF-CRP15-201504.
Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/10/18
Y1 - 2018/10/18
N2 - Progress in photoacoustic (PA) and magnetic resonance imaging (MRI) bimodal contrast agents has been achieved mainly by utilizing the imaging capability of single or multiple components and consequently realizing the desired application for both imaging modalities. However, the mechanism of the mutual influence between components within a single nanoformulation, which is the key to developing high-performance multimodal contrast agents, has yet to be fully understood. Herein, by integrating conjugated polymers (CPs) with iron oxide (IO) nanoparticles using an amphiphilic polymer, a bimodal contrast agent named CP-IO is developed, displaying 45% amplified PA signal intensity as compared to bare CP nanoparticle, while the performance of MRI is not affected. Further experimental and theoretical simulation results reveal that the addition of IO nanoparticles in CP-IO nanocomposites contributes to this PA signal amplification through a synergistic effect of additional heat generation and faster heat dissipation. Besides, the feasibility of CP-IO nanocomposites acting as PA-MRI bimodal contrast agents is validated through in vivo tumor imaging using mice models. From this study, it is demonstrated that a delicately designed structural arrangement of various components in a contrast agent could potentially lead to a superior performance in the imaging capability.
AB - Progress in photoacoustic (PA) and magnetic resonance imaging (MRI) bimodal contrast agents has been achieved mainly by utilizing the imaging capability of single or multiple components and consequently realizing the desired application for both imaging modalities. However, the mechanism of the mutual influence between components within a single nanoformulation, which is the key to developing high-performance multimodal contrast agents, has yet to be fully understood. Herein, by integrating conjugated polymers (CPs) with iron oxide (IO) nanoparticles using an amphiphilic polymer, a bimodal contrast agent named CP-IO is developed, displaying 45% amplified PA signal intensity as compared to bare CP nanoparticle, while the performance of MRI is not affected. Further experimental and theoretical simulation results reveal that the addition of IO nanoparticles in CP-IO nanocomposites contributes to this PA signal amplification through a synergistic effect of additional heat generation and faster heat dissipation. Besides, the feasibility of CP-IO nanocomposites acting as PA-MRI bimodal contrast agents is validated through in vivo tumor imaging using mice models. From this study, it is demonstrated that a delicately designed structural arrangement of various components in a contrast agent could potentially lead to a superior performance in the imaging capability.
KW - conjugated polymer
KW - finite element analysis
KW - iron oxide nanoparticle
KW - magnetic resonance imaging
KW - photoacoustic imaging
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U2 - 10.1002/smll.201800652
DO - 10.1002/smll.201800652
M3 - Article
C2 - 30247812
AN - SCOPUS:85053755960
SN - 1613-6810
VL - 14
JO - Small
JF - Small
IS - 42
M1 - 1800652
ER -