Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair

Zhimin Peng; Zhongping Liao; Barbara Dziegielewska; Yoshi Matsumoto; Stefani Thomas; Yunhu Wan; Austin Yang; Alan E. Tomkinson

doi:10.1074/jbc.M112.383570

Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair

Zhimin Peng, Zhongping Liao, Barbara Dziegielewska, Yoshi Matsumoto, Stefani Thomas, Yunhu Wan, Austin Yang, Alan E. Tomkinson

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: Phosphorylation of human DNA ligase I (hLigI) regulates its participation in DNA replication and repair. Results: Identification of a single phosphorylation site that regulates the interaction of hLigI with replication factor C (RFC). Conclusion: Interaction between hLigI and RFC is critical for DNA replication and repair. Significance: We provide insights into the mechanism by which a single phosphorylation site regulates the cellular functions of hLigI.

Original language	English (US)
Pages (from-to)	36711-36719
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.383570
State	Published - Oct 26 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M112.383570

Cite this

@article{e809c9404a3042f9988cc8e44f230ee3,

title = "Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair",

abstract = "Background: Phosphorylation of human DNA ligase I (hLigI) regulates its participation in DNA replication and repair. Results: Identification of a single phosphorylation site that regulates the interaction of hLigI with replication factor C (RFC). Conclusion: Interaction between hLigI and RFC is critical for DNA replication and repair. Significance: We provide insights into the mechanism by which a single phosphorylation site regulates the cellular functions of hLigI.",

author = "Zhimin Peng and Zhongping Liao and Barbara Dziegielewska and Yoshi Matsumoto and Stefani Thomas and Yunhu Wan and Austin Yang and Tomkinson, {Alan E.}",

year = "2012",

month = oct,

day = "26",

doi = "10.1074/jbc.M112.383570",

language = "English (US)",

volume = "287",

pages = "36711--36719",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "44",

}

TY - JOUR

T1 - Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair

AU - Peng, Zhimin

AU - Liao, Zhongping

AU - Dziegielewska, Barbara

AU - Matsumoto, Yoshi

AU - Thomas, Stefani

AU - Wan, Yunhu

AU - Yang, Austin

AU - Tomkinson, Alan E.

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: Phosphorylation of human DNA ligase I (hLigI) regulates its participation in DNA replication and repair. Results: Identification of a single phosphorylation site that regulates the interaction of hLigI with replication factor C (RFC). Conclusion: Interaction between hLigI and RFC is critical for DNA replication and repair. Significance: We provide insights into the mechanism by which a single phosphorylation site regulates the cellular functions of hLigI.

AB - Background: Phosphorylation of human DNA ligase I (hLigI) regulates its participation in DNA replication and repair. Results: Identification of a single phosphorylation site that regulates the interaction of hLigI with replication factor C (RFC). Conclusion: Interaction between hLigI and RFC is critical for DNA replication and repair. Significance: We provide insights into the mechanism by which a single phosphorylation site regulates the cellular functions of hLigI.

UR - http://www.scopus.com/inward/record.url?scp=84868231295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868231295&partnerID=8YFLogxK

U2 - 10.1074/jbc.M112.383570

DO - 10.1074/jbc.M112.383570

M3 - Article

C2 - 22952233

AN - SCOPUS:84868231295

SN - 0021-9258

VL - 287

SP - 36711

EP - 36719

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 44

ER -

Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this