Phosphorylation of proteins by inositol pyrophosphates

Adolfo Saiardi, Rashna Bhandari, Adam C. Resnick, Adele M. Snowman, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

The inositol pyrophosphates IP7 and IP8 contain highly energetic pyrophosphate bonds. Although implicated in various biologic functions, their molecular sites of action have not been clarified. Using radiolabeled IP7, we detected phosphorylation of multiple eukaryotic proteins. We also observed phosphorylation of endogenous proteins by endogenous IP7 in yeast. Phosphorylation by IP7 is nonenzymatic and may represent a novel intracellular signaling mechanism.

Original languageEnglish (US)
Pages (from-to)2101-2105
Number of pages5
JournalScience
Volume306
Issue number5704
DOIs
StatePublished - Dec 17 2004

ASJC Scopus subject areas

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