Phosphorylation of nuclear matrix proteins in isolated regenerating rat liver nuclei

Steven L. Allen; Ronald Berezney; Donald S. Coffey

doi:10.1016/0006-291X(77)91296-7

Phosphorylation of nuclear matrix proteins in isolated regenerating rat liver nuclei

Steven L. Allen, Ronald Berezney, Donald S. Coffey

School of Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The phosphorylation of nuclear matrix proteins from normal and regenerating rat liver nuclei was examined using an in vitro system of isolated nuclei and γ-³²P-ATP. Phosphorylation of the nuclear matrix proteins was 2-3 fold higher than that of the total nuclear proteins in normal nuclei. The level of phosphorylation of the matrix proteins was enhanced an additional three fold at a period in liver regeneration (12 hours) just preceding the onset of DNA synthesis.

Original language	English (US)
Pages (from-to)	111-116
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	75
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(77)91296-7
State	Published - Mar 7 1977

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "The phosphorylation of nuclear matrix proteins from normal and regenerating rat liver nuclei was examined using an in vitro system of isolated nuclei and γ-32P-ATP. Phosphorylation of the nuclear matrix proteins was 2-3 fold higher than that of the total nuclear proteins in normal nuclei. The level of phosphorylation of the matrix proteins was enhanced an additional three fold at a period in liver regeneration (12 hours) just preceding the onset of DNA synthesis.",

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AU - Allen, Steven L.

AU - Berezney, Ronald

AU - Coffey, Donald S.

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N2 - The phosphorylation of nuclear matrix proteins from normal and regenerating rat liver nuclei was examined using an in vitro system of isolated nuclei and γ-32P-ATP. Phosphorylation of the nuclear matrix proteins was 2-3 fold higher than that of the total nuclear proteins in normal nuclei. The level of phosphorylation of the matrix proteins was enhanced an additional three fold at a period in liver regeneration (12 hours) just preceding the onset of DNA synthesis.

AB - The phosphorylation of nuclear matrix proteins from normal and regenerating rat liver nuclei was examined using an in vitro system of isolated nuclei and γ-32P-ATP. Phosphorylation of the nuclear matrix proteins was 2-3 fold higher than that of the total nuclear proteins in normal nuclei. The level of phosphorylation of the matrix proteins was enhanced an additional three fold at a period in liver regeneration (12 hours) just preceding the onset of DNA synthesis.

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JO - Biochemical and Biophysical Research Communications

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Phosphorylation of nuclear matrix proteins in isolated regenerating rat liver nuclei

Abstract

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