Phosphorus-31 magnetic resonance spectra reveal prolonged intracellular acidosis in the brain following subarachnoid hemorrhage

Nicholas S R Brooke; Ronald Ouwerkerk; Christopher B T Adams; George K. Radda; John G G Ledingham; Bheeshma Rajagopalan

Phosphorus-31 magnetic resonance spectra reveal prolonged intracellular acidosis in the brain following subarachnoid hemorrhage

Nicholas S R Brooke, Ronald Ouwerkerk, Christopher B T Adams, George K. Radda, John G G Ledingham, Bheeshma Rajagopalan

Research output: Contribution to journal › Article › peer-review

Abstract

Subarachnoid hemorrhage may be complicated by cerebral ischemia which, though reversible initially, can progress to an irreversible neurological deficit. ³¹P magnetic resonance spectroscopy, which can determine intracellular pH and thus detect areas of ischemia noninvasively, was applied to 10 patients on 30 occasions, at various times after subarachnoid hemorrhage. In 5 of them, there were focal areas of the brain in which the intracellular pH was reduced to 31P magnetic resonance spectroscopy of the brain offers a method of detecting cerebral ischemia and, more importantly, of assessing methods of treatment.

Original language	English (US)
Pages (from-to)	1903-1907
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	91
Issue number	5
State	Published - Mar 1 1994
Externally published	Yes

Keywords

cerebral ischemia
intracellular pH
nuclear magnetic resonance in vivo

ASJC Scopus subject areas

Genetics
General

Cite this

Phosphorus-31 magnetic resonance spectra reveal prolonged intracellular acidosis in the brain following subarachnoid hemorrhage. / Brooke, Nicholas S R; Ouwerkerk, Ronald; Adams, Christopher B T et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, No. 5, 01.03.1994, p. 1903-1907.

Research output: Contribution to journal › Article › peer-review

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AU - Ledingham, John G G

AU - Rajagopalan, Bheeshma

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N2 - Subarachnoid hemorrhage may be complicated by cerebral ischemia which, though reversible initially, can progress to an irreversible neurological deficit. 31P magnetic resonance spectroscopy, which can determine intracellular pH and thus detect areas of ischemia noninvasively, was applied to 10 patients on 30 occasions, at various times after subarachnoid hemorrhage. In 5 of them, there were focal areas of the brain in which the intracellular pH was reduced to 31P magnetic resonance spectroscopy of the brain offers a method of detecting cerebral ischemia and, more importantly, of assessing methods of treatment.

AB - Subarachnoid hemorrhage may be complicated by cerebral ischemia which, though reversible initially, can progress to an irreversible neurological deficit. 31P magnetic resonance spectroscopy, which can determine intracellular pH and thus detect areas of ischemia noninvasively, was applied to 10 patients on 30 occasions, at various times after subarachnoid hemorrhage. In 5 of them, there were focal areas of the brain in which the intracellular pH was reduced to 31P magnetic resonance spectroscopy of the brain offers a method of detecting cerebral ischemia and, more importantly, of assessing methods of treatment.

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KW - intracellular pH

KW - nuclear magnetic resonance in vivo

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Phosphorus-31 magnetic resonance spectra reveal prolonged intracellular acidosis in the brain following subarachnoid hemorrhage

Abstract

Keywords

ASJC Scopus subject areas

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