Phosphorus-31 magnetic resonance spectra reveal prolonged intracellular acidosis in the brain following subarachnoid hemorrhage

Nicholas S R Brooke, Ronald Ouwerkerk, Christopher B T Adams, George K. Radda, John G G Ledingham, Bheeshma Rajagopalan

Research output: Contribution to journalArticle

Abstract

Subarachnoid hemorrhage may be complicated by cerebral ischemia which, though reversible initially, can progress to an irreversible neurological deficit. 31P magnetic resonance spectroscopy, which can determine intracellular pH and thus detect areas of ischemia noninvasively, was applied to 10 patients on 30 occasions, at various times after subarachnoid hemorrhage. In 5 of them, there were focal areas of the brain in which the intracellular pH was reduced to 31P magnetic resonance spectroscopy of the brain offers a method of detecting cerebral ischemia and, more importantly, of assessing methods of treatment.

Original languageEnglish (US)
Pages (from-to)1903-1907
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number5
StatePublished - Mar 1 1994
Externally publishedYes

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Subarachnoid Hemorrhage
Acidosis
Brain Ischemia
Phosphorus
Magnetic Resonance Spectroscopy
Brain
Ischemia
Therapeutics

Keywords

  • cerebral ischemia
  • intracellular pH
  • nuclear magnetic resonance in vivo

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Phosphorus-31 magnetic resonance spectra reveal prolonged intracellular acidosis in the brain following subarachnoid hemorrhage. / Brooke, Nicholas S R; Ouwerkerk, Ronald; Adams, Christopher B T; Radda, George K.; Ledingham, John G G; Rajagopalan, Bheeshma.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, No. 5, 01.03.1994, p. 1903-1907.

Research output: Contribution to journalArticle

Brooke, Nicholas S R ; Ouwerkerk, Ronald ; Adams, Christopher B T ; Radda, George K. ; Ledingham, John G G ; Rajagopalan, Bheeshma. / Phosphorus-31 magnetic resonance spectra reveal prolonged intracellular acidosis in the brain following subarachnoid hemorrhage. In: Proceedings of the National Academy of Sciences of the United States of America. 1994 ; Vol. 91, No. 5. pp. 1903-1907.
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