Phospholipase C-γ: Diverse roles in receptor-mediated calcium signaling

Randen L. Patterson, Damian B. Van Rossum, Nikolas Nikolaidis, Donald L. Gill, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Ca2+ is a universal signal: the dynamic changes in its release and entry trigger a plethora of cellular responses. Central to this schema are members of the phospholipase C (PLC) superfamily, which relay information from the activated receptor to downstream signal cascades by production of second-messenger molecules. Recent studies reveal that, in addition to its enzymatic activity, PLC-γ regulates Ca2+ entry via the formation of an intermolecular lipid-binding domain with canonical transient receptor potential 3 (TRPC3) ion channels. This complex, in turn, controls TRPC3 trafficking and cell-surface expression. Thus, TRPC3 ion channels are functionally linked to both lipase-dependent and -independent activities of PLC-γ. Understanding the underlying molecular mechanisms that regulate this complex will probably clarify the processes of receptor-activated Ca 2+ entry.

Original languageEnglish (US)
Pages (from-to)688-697
Number of pages10
JournalTrends in Biochemical Sciences
Volume30
Issue number12
DOIs
StatePublished - Dec 2005

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Calcium Signaling
Type C Phospholipases
Calcium
Second Messenger Systems
Lipase
Lipids
Molecules
TRPC3 cation channel

ASJC Scopus subject areas

  • Biochemistry

Cite this

Phospholipase C-γ : Diverse roles in receptor-mediated calcium signaling. / Patterson, Randen L.; Van Rossum, Damian B.; Nikolaidis, Nikolas; Gill, Donald L.; Snyder, Solomon H.

In: Trends in Biochemical Sciences, Vol. 30, No. 12, 12.2005, p. 688-697.

Research output: Contribution to journalArticle

Patterson, Randen L. ; Van Rossum, Damian B. ; Nikolaidis, Nikolas ; Gill, Donald L. ; Snyder, Solomon H. / Phospholipase C-γ : Diverse roles in receptor-mediated calcium signaling. In: Trends in Biochemical Sciences. 2005 ; Vol. 30, No. 12. pp. 688-697.
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