Phospholipase Cγ1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE

Keqiang Ye, Bahman Aghdasi, Hongbo R. Luo, John L. Moriarity, Frederick Y. Wu, Jenny J. Hong, K. Joseph Hurt, Sun Sik Bae, Pann Ghill Suh, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Phospholipase Cγ1 (PLC-γ1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-γ1 also has mitogenic activity upon growth-factor-dependent tyrosine phophorylation; however, this activity is not dependent on the phospholipase activity of PLC-γ1, but requires an SH3 domain. Here, we demonstrate that PLC-γ1 acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer). PIKE is a nuclear GTPase that activates nuclear PI(3)K activity, and mediates the physiological activation by nerve growth factor (NGF) of nuclear PI(3)K activity. This enzymatic activity accounts for the mitogenic properties of PLC-γ1.

Original languageEnglish (US)
Pages (from-to)541-544
Number of pages4
JournalNature
Volume415
Issue number6871
DOIs
StatePublished - Jan 31 2002

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Guanine Nucleotide Exchange Factors
GTP Phosphohydrolases
Phosphatidylinositol 3-Kinases
Inositol 1,4,5-Trisphosphate
src Homology Domains
Phospholipases
Diglycerides
Second Messenger Systems
Nerve Growth Factor
Phosphatidylinositols
Tyrosine
Intercellular Signaling Peptides and Proteins
phospholipase C1

ASJC Scopus subject areas

  • General

Cite this

Ye, K., Aghdasi, B., Luo, H. R., Moriarity, J. L., Wu, F. Y., Hong, J. J., ... Snyder, S. H. (2002). Phospholipase Cγ1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature, 415(6871), 541-544. https://doi.org/10.1038/415541a

Phospholipase Cγ1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. / Ye, Keqiang; Aghdasi, Bahman; Luo, Hongbo R.; Moriarity, John L.; Wu, Frederick Y.; Hong, Jenny J.; Joseph Hurt, K.; Sik Bae, Sun; Suh, Pann Ghill; Snyder, Solomon H.

In: Nature, Vol. 415, No. 6871, 31.01.2002, p. 541-544.

Research output: Contribution to journalArticle

Ye, K, Aghdasi, B, Luo, HR, Moriarity, JL, Wu, FY, Hong, JJ, Joseph Hurt, K, Sik Bae, S, Suh, PG & Snyder, SH 2002, 'Phospholipase Cγ1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE', Nature, vol. 415, no. 6871, pp. 541-544. https://doi.org/10.1038/415541a
Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ et al. Phospholipase Cγ1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature. 2002 Jan 31;415(6871):541-544. https://doi.org/10.1038/415541a
Ye, Keqiang ; Aghdasi, Bahman ; Luo, Hongbo R. ; Moriarity, John L. ; Wu, Frederick Y. ; Hong, Jenny J. ; Joseph Hurt, K. ; Sik Bae, Sun ; Suh, Pann Ghill ; Snyder, Solomon H. / Phospholipase Cγ1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. In: Nature. 2002 ; Vol. 415, No. 6871. pp. 541-544.
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