Phosphoinositide signaling plays a key role in cytokinesis

Chris Janetopoulos, Peter Devreotes

Research output: Contribution to journalShort surveypeer-review

82 Scopus citations


To perform the vital functions of motility and division, cells must undergo dramatic shifts in cell polarity. Recent evidence suggests that polarized distributions of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, which are clearly important for regulating cell morphology during migration, also play an important role during the final event in cell division, which is cytokinesis. Thus, there is a critical interplay between the membrane phosphoinositides and the cytoskeletal cortex that regulates the complex series of cell shape changes that accompany these two processes.

Original languageEnglish (US)
Pages (from-to)485-490
Number of pages6
JournalJournal of Cell Biology
Issue number4
StatePublished - Aug 14 2006

ASJC Scopus subject areas

  • Cell Biology


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