Phosphoinositide signaling plays a key role in cytokinesis

Chris Janetopoulos, Peter Devreotes

Research output: Contribution to journalShort surveypeer-review

Abstract

To perform the vital functions of motility and division, cells must undergo dramatic shifts in cell polarity. Recent evidence suggests that polarized distributions of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, which are clearly important for regulating cell morphology during migration, also play an important role during the final event in cell division, which is cytokinesis. Thus, there is a critical interplay between the membrane phosphoinositides and the cytoskeletal cortex that regulates the complex series of cell shape changes that accompany these two processes.

Original languageEnglish (US)
Pages (from-to)485-490
Number of pages6
JournalJournal of Cell Biology
Volume174
Issue number4
DOIs
StatePublished - Aug 14 2006

ASJC Scopus subject areas

  • Cell Biology

Fingerprint

Dive into the research topics of 'Phosphoinositide signaling plays a key role in cytokinesis'. Together they form a unique fingerprint.

Cite this