Phosphoinositide signaling plays a key role in cytokinesis

Chris Janetopoulos, Peter Devreotes

Research output: Contribution to journalShort survey

Abstract

To perform the vital functions of motility and division, cells must undergo dramatic shifts in cell polarity. Recent evidence suggests that polarized distributions of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, which are clearly important for regulating cell morphology during migration, also play an important role during the final event in cell division, which is cytokinesis. Thus, there is a critical interplay between the membrane phosphoinositides and the cytoskeletal cortex that regulates the complex series of cell shape changes that accompany these two processes.

Original languageEnglish (US)
Pages (from-to)485-490
Number of pages6
JournalJournal of Cell Biology
Volume174
Issue number4
DOIs
StatePublished - Aug 14 2006

ASJC Scopus subject areas

  • Cell Biology

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