TY - JOUR
T1 - Phosphoinositide signaling plays a key role in cytokinesis
AU - Janetopoulos, Chris
AU - Devreotes, Peter
PY - 2006/8/14
Y1 - 2006/8/14
N2 - To perform the vital functions of motility and division, cells must undergo dramatic shifts in cell polarity. Recent evidence suggests that polarized distributions of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, which are clearly important for regulating cell morphology during migration, also play an important role during the final event in cell division, which is cytokinesis. Thus, there is a critical interplay between the membrane phosphoinositides and the cytoskeletal cortex that regulates the complex series of cell shape changes that accompany these two processes.
AB - To perform the vital functions of motility and division, cells must undergo dramatic shifts in cell polarity. Recent evidence suggests that polarized distributions of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, which are clearly important for regulating cell morphology during migration, also play an important role during the final event in cell division, which is cytokinesis. Thus, there is a critical interplay between the membrane phosphoinositides and the cytoskeletal cortex that regulates the complex series of cell shape changes that accompany these two processes.
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U2 - 10.1083/jcb.200603156
DO - 10.1083/jcb.200603156
M3 - Short survey
C2 - 16908667
AN - SCOPUS:33747161898
SN - 0021-9525
VL - 174
SP - 485
EP - 490
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 4
ER -