Phosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality

Simon G. Anderson, David C. Hutchings, Mark Woodward, Kazem Rahimi, Martin K. Rutter, Mike Kirby, Geoff Hackett, Andrew W. Trafford, Adrian H. Heald

Research output: Contribution to journalArticle

Abstract

Objective Experimental evidence has shown potential cardioprotective actions of phosphodiesterase type-5 inhibitors (PDE5is). We investigated whether PDE5i use in patients with type 2 diabetes, with high-attendant cardiovascular risk, was associated with altered mortality in a retrospective cohort study. Research design and methods Between January 2007 and May 2015, 5956 men aged 40-89 years diagnosed with type 2 diabetes before 2007 were identified from anonymised electronic health records of 42 general practices in Cheshire, UK, and were followed for 7.5 years. HRs from multivariable survival (accelerated failure time, Weibull) models were used to describe the association between on-demand PDE5i use and all-cause mortality. Results Compared with non-users, men who are prescribed PDE5is (n=1359) experienced lower percentage of deaths during follow-up (19.1% vs 23.8%) and lower risk of all-cause mortality (unadjusted HR=0.69 (95% CI: 0.64 to 0.79); p<0.001)). The reduction in risk of mortality (HR=0.54 (0.36 to 0.80); p=0.002) remained after adjusting for age, estimated glomerular filtration rate, smoking status, prior cerebrovascular accident (CVA) hypertension, prior myocardial infarction (MI), systolic blood pressure, use of statin, metformin, aspirin and â-blocker medication. PDE5i users had lower rates of incident MI (incidence rate ratio (0.62 (0.49 to 0.80), p<0.0001) with lower mortality (25.7% vs 40.1% deaths; age-adjusted HR=0.60 (0.54 to 0.69); p=0.001) compared with non-users within this subgroup. Conclusion In a population of men with type 2 diabetes, use of PDE5is was associated with lower risk of overall mortality and mortality in those with a history of acute MI.

Original languageEnglish (US)
Pages (from-to)1750-1756
Number of pages7
JournalHeart
Volume102
Issue number21
DOIs
StatePublished - Nov 1 2016

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Anderson, S. G., Hutchings, D. C., Woodward, M., Rahimi, K., Rutter, M. K., Kirby, M., Hackett, G., Trafford, A. W., & Heald, A. H. (2016). Phosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality. Heart, 102(21), 1750-1756. https://doi.org/10.1136/heartjnl-2015-309223