Phosphatidylinositol 3-Kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction. Contribution to transforming growth factor β1-induced Epstein-Barr virus reactivation

Lassad Oussaief; Aurélie Hippocrate; Vanessa Ramirez; Aurore Rampanou; Wei Zhang; David Meyers; Philip Cole; Ridha Khelifa; Irène Joab

doi:10.1074/jbc.M109.036483

Phosphatidylinositol 3-Kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction. Contribution to transforming growth factor β1-induced Epstein-Barr virus reactivation

Lassad Oussaief, Aurélie Hippocrate, Vanessa Ramirez, Aurore Rampanou, Wei Zhang, David Meyers, Philip Cole, Ridha Khelifa, Irène Joab

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Epstein-Barr virus, a ubiquitous human herpesvirus, is associated with the development of carcinomas and lymphomas. We previously showed that transforming growth factor β1 (TGF-β1) mediated the virus to enter the lytic cycle, which is triggered by expression of Z Epstein-Barr virus replication activator (ZEBRA), through the ERK 1/2 MAPK signaling pathway. We report here that Akt, activated downstream from ERK 1/2, was required for TGF-β1-induced ZEBRA expression and enabled Smad3, a mediator of TGF-β1 signaling, to be acetylated by direct interaction with the co-activator CREB-binding protein and then to regulate TGF-β1-induced ZEBRA expression.

Original language	English (US)
Pages (from-to)	23912-23924
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	284
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M109.036483
State	Published - Sep 4 2009

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Oussaief, L., Hippocrate, A., Ramirez, V., Rampanou, A., Zhang, W., Meyers, D., Cole, P., Khelifa, R., & Joab, I. (2009). Phosphatidylinositol 3-Kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction. Contribution to transforming growth factor β1-induced Epstein-Barr virus reactivation. Journal of Biological Chemistry, 284(36), 23912-23924. https://doi.org/10.1074/jbc.M109.036483

Phosphatidylinositol 3-Kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction. Contribution to transforming growth factor β1-induced Epstein-Barr virus reactivation. / Oussaief, Lassad; Hippocrate, Aurélie; Ramirez, Vanessa et al.
In: Journal of Biological Chemistry, Vol. 284, No. 36, 04.09.2009, p. 23912-23924.

Research output: Contribution to journal › Article › peer-review

Oussaief, L, Hippocrate, A, Ramirez, V, Rampanou, A, Zhang, W, Meyers, D, Cole, P, Khelifa, R & Joab, I 2009, 'Phosphatidylinositol 3-Kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction. Contribution to transforming growth factor β1-induced Epstein-Barr virus reactivation', Journal of Biological Chemistry, vol. 284, no. 36, pp. 23912-23924. https://doi.org/10.1074/jbc.M109.036483

Oussaief L, Hippocrate A, Ramirez V, Rampanou A, Zhang W, Meyers D et al. Phosphatidylinositol 3-Kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction. Contribution to transforming growth factor β1-induced Epstein-Barr virus reactivation. Journal of Biological Chemistry. 2009 Sep 4;284(36):23912-23924. doi: 10.1074/jbc.M109.036483

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abstract = "Epstein-Barr virus, a ubiquitous human herpesvirus, is associated with the development of carcinomas and lymphomas. We previously showed that transforming growth factor β1 (TGF-β1) mediated the virus to enter the lytic cycle, which is triggered by expression of Z Epstein-Barr virus replication activator (ZEBRA), through the ERK 1/2 MAPK signaling pathway. We report here that Akt, activated downstream from ERK 1/2, was required for TGF-β1-induced ZEBRA expression and enabled Smad3, a mediator of TGF-β1 signaling, to be acetylated by direct interaction with the co-activator CREB-binding protein and then to regulate TGF-β1-induced ZEBRA expression.",

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AU - Zhang, Wei

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AU - Cole, Philip

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Phosphatidylinositol 3-Kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction. Contribution to transforming growth factor β1-induced Epstein-Barr virus reactivation

Abstract

ASJC Scopus subject areas

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