TY - JOUR
T1 - Phosphatidylinositol 3-Kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction. Contribution to transforming growth factor β1-induced Epstein-Barr virus reactivation
AU - Oussaief, Lassad
AU - Hippocrate, Aurélie
AU - Ramirez, Vanessa
AU - Rampanou, Aurore
AU - Zhang, Wei
AU - Meyers, David
AU - Cole, Philip
AU - Khelifa, Ridha
AU - Joab, Irène
PY - 2009/9/4
Y1 - 2009/9/4
N2 - Epstein-Barr virus, a ubiquitous human herpesvirus, is associated with the development of carcinomas and lymphomas. We previously showed that transforming growth factor β1 (TGF-β1) mediated the virus to enter the lytic cycle, which is triggered by expression of Z Epstein-Barr virus replication activator (ZEBRA), through the ERK 1/2 MAPK signaling pathway. We report here that Akt, activated downstream from ERK 1/2, was required for TGF-β1-induced ZEBRA expression and enabled Smad3, a mediator of TGF-β1 signaling, to be acetylated by direct interaction with the co-activator CREB-binding protein and then to regulate TGF-β1-induced ZEBRA expression.
AB - Epstein-Barr virus, a ubiquitous human herpesvirus, is associated with the development of carcinomas and lymphomas. We previously showed that transforming growth factor β1 (TGF-β1) mediated the virus to enter the lytic cycle, which is triggered by expression of Z Epstein-Barr virus replication activator (ZEBRA), through the ERK 1/2 MAPK signaling pathway. We report here that Akt, activated downstream from ERK 1/2, was required for TGF-β1-induced ZEBRA expression and enabled Smad3, a mediator of TGF-β1 signaling, to be acetylated by direct interaction with the co-activator CREB-binding protein and then to regulate TGF-β1-induced ZEBRA expression.
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U2 - 10.1074/jbc.M109.036483
DO - 10.1074/jbc.M109.036483
M3 - Article
C2 - 19589780
AN - SCOPUS:69949139699
SN - 0021-9258
VL - 284
SP - 23912
EP - 23924
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 36
ER -