Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonance

Paul A. Bottomley, Christopher J. Hardy, Peter B. Roemer

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiac‐gated phosphorus (31P) nuclear magnetic resonance (NMR) spectroscopic imaging with surface coils resolves in three dimensions the spatial distribution of high energy phosphate metabolites in the human heart noninvasively. 31P spectra derive from 6‐ to 14‐cm3 volumes of myocardium in the anterior left ventricle, septum, and apex, at depths of up to about 8 cm from the chest, as identified by proton (1H) NMR anatomical images acquired without moving the subject. Spectroscopic images are acquired in 9 to 21 min at 1.5 T. Metabolite concentrations are quantified with reference to a standard located outside the chest, yielding normal in vivo concentrations of phosphocreatine and adenosine triphosphate of about 11.0 ± 2.7 (SD) and 6.9 ± 1.6 μmol/g of wet heart tissue, respectively. High energy phosphate contents did not vary significantly with location in the normal myocardium, but 2,3‐diphosphoglycerate signals from blood varied with Subject and location. © 1990 Academic Press, Inc.

Original languageEnglish (US)
Pages (from-to)425-434
Number of pages10
JournalMagnetic resonance in medicine
Volume14
Issue number3
DOIs
StatePublished - Jun 1990
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonance'. Together they form a unique fingerprint.

Cite this