Phosgene exposure: Mechanism of injury and treatment strategies

Jonathan Borak, Werner F. Diller

Research output: Contribution to journalArticle

Abstract

Phosgene (carbonyl chloride, CAS 75-44-5) is a highly reactive gas of historical interest and current industrial importance. Phosgene has also proved to be a useful model for the study of those biochemical mechanisms that lead to permeability-type pulmonary edema (adult respiratory distress syndrome). In turn, the study of phosgene-induced adult respiratory distress syndrome has provided insights leading to revised treatment strategies for exposure victims. We summarized recent findings on the mechanisms of phosgene-induced pulmonary edema and their implications for victim management. In light of that research, we also provide a comprehensive approach to the management and treatment of phosgene exposure victims.

Original languageEnglish (US)
Pages (from-to)110-119
Number of pages10
JournalJournal of Occupational and Environmental Medicine
Volume43
Issue number2
StatePublished - 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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