Abstract
Summary: Acute kidney injury (AKI) is a common complication in hospitalized patients and is associated with adverse short- and long-term outcomes. AKI is diagnosed by serum creatinine (SCr)-based consensus definitions that capture an abrupt decrease in glomerular filtration rate associated with AKI. However, SCr-based AKI definitions lack sensitivity and specificity for diagnosing structural kidney injury. Moreover, AKI is a heterogeneous condition consisting of distinct phenotypes based on its etiology, prognosis, and molecular pathways, and that may potentially require different therapies. SCr-based AKI definitions provide no information on these AKI phenotypes. This review highlights traditional and novel tools that overcome the limitations of SCr-based AKI definitions to improve AKI phenotyping.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3-11 |
| Number of pages | 9 |
| Journal | Seminars in Nephrology |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2018 |
| Externally published | Yes |
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Keywords
- AKI
- biomarkers
- creatinine
- cystatin C
- furosemide
- IL-18
- IL-6
- KIM-1
- L-FABP
- NGAL
- urinary casts
- urine microscopy
ASJC Scopus subject areas
- Nephrology
Cite this
Phenotyping of Acute Kidney Injury : Beyond Serum Creatinine. / Moledina, Dennis G.; Parikh, Chirag.
In: Seminars in Nephrology, Vol. 38, No. 1, 01.01.2018, p. 3-11.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Phenotyping of Acute Kidney Injury
T2 - Beyond Serum Creatinine
AU - Moledina, Dennis G.
AU - Parikh, Chirag
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Summary: Acute kidney injury (AKI) is a common complication in hospitalized patients and is associated with adverse short- and long-term outcomes. AKI is diagnosed by serum creatinine (SCr)-based consensus definitions that capture an abrupt decrease in glomerular filtration rate associated with AKI. However, SCr-based AKI definitions lack sensitivity and specificity for diagnosing structural kidney injury. Moreover, AKI is a heterogeneous condition consisting of distinct phenotypes based on its etiology, prognosis, and molecular pathways, and that may potentially require different therapies. SCr-based AKI definitions provide no information on these AKI phenotypes. This review highlights traditional and novel tools that overcome the limitations of SCr-based AKI definitions to improve AKI phenotyping.
AB - Summary: Acute kidney injury (AKI) is a common complication in hospitalized patients and is associated with adverse short- and long-term outcomes. AKI is diagnosed by serum creatinine (SCr)-based consensus definitions that capture an abrupt decrease in glomerular filtration rate associated with AKI. However, SCr-based AKI definitions lack sensitivity and specificity for diagnosing structural kidney injury. Moreover, AKI is a heterogeneous condition consisting of distinct phenotypes based on its etiology, prognosis, and molecular pathways, and that may potentially require different therapies. SCr-based AKI definitions provide no information on these AKI phenotypes. This review highlights traditional and novel tools that overcome the limitations of SCr-based AKI definitions to improve AKI phenotyping.
KW - AKI
KW - biomarkers
KW - creatinine
KW - cystatin C
KW - furosemide
KW - IL-18
KW - IL-6
KW - KIM-1
KW - L-FABP
KW - NGAL
KW - urinary casts
KW - urine microscopy
UR - http://www.scopus.com/inward/record.url?scp=85033466668&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85033466668&partnerID=8YFLogxK
U2 - 10.1016/j.semnephrol.2017.09.002
DO - 10.1016/j.semnephrol.2017.09.002
M3 - Review article
C2 - 29291759
AN - SCOPUS:85033466668
VL - 38
SP - 3
EP - 11
JO - Seminars in Nephrology
JF - Seminars in Nephrology
SN - 0270-9295
IS - 1
ER -