Phenotypic plasticity and the epigenetics of human disease

Research output: Contribution to journalReview articlepeer-review

Abstract

It is becoming clear that epigenetic changes are involved in human disease as well as during normal development. A unifying theme of disease epigenetics is defects in phenotypic plasticity - cells' ability to change their behaviour in response to internal or external environmental cues. This model proposes that hereditary disorders of the epigenetic apparatus lead to developmental defects, that cancer epigenetics involves disruption of the stem-cell programme, and that common diseases with late-onset phenotypes involve interactions between the epigenome, the genome and the environment. Increased understanding of epigenetic-disease mechanisms could lead to disease-risk stratification for targeted intervention and to targeted therapies.

Original languageEnglish (US)
Pages (from-to)433-440
Number of pages8
JournalNature
Volume447
Issue number7143
DOIs
StatePublished - May 24 2007

ASJC Scopus subject areas

  • General

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